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| http://dx.doi.org/10.5021/ad.2013.25.3.392 | DOI Listing |
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ADSCs-derived exosomes suppress macrophage ferroptosis via the SIRT1/NRF2 signaling axis to alleviate acute lung injury in sepsis.
Int Immunopharmacol
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Department of Burns and Cutaneous Surgery, Xijing Hospital, the Fourth Military Medical University, 127 Changle West Road, Xi'an, Shaanxi 710032, China. Electronic address:
Acute lung injury being one of the earliest and most severe complications during sepsis and macrophages play a key role in this process. To investigate the regulatory effects and potential mechanisms of adipose mesenchymal stem cell derived-exosomes (ADSC-exo) on macrophages and septic mice, ADSCs-exo was administrated to both LPS-induced macrophage and cecal ligation and puncture (CLP) induced sepsis mice. ADSCs-exo was confirmed to inhibit M1 polarization of macrophages and to reduce excessive inflammation.
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Mod Rheumatol Case Rep
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Department of Rheumatology, Tohoku University Hospital, Sendai, Japan.
The skin ulcers sometimes appear in patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis (DM), and usually associates with disease activity. Here, we report a case of 41-year-old woman with anti-MDA5 antibody-positive DM, who developed refractory skin ulcers during the remission induction therapy, which were proven to be associated with clinically silent Staphylococcus aureus bacteremia with septic thrombi in her lung. The patient was referred to our hospital for the treatment of amyopathic DM with interstitial lung disease.
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Serviço de Gastrenterologia, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal.
Article Synopsis
- Hematopoietic stem cell transplantation (HSCT) can lead to serious complications like sinusoidal obstruction syndrome (SOS) and graft-versus-host disease (GVHD), which may show overlapping symptoms but rarely occur together.
- A case of a 29-year-old male with acute myeloid leukemia experienced hyperbilirubinemia and signs of SOS early after HSCT, followed by the development of GVHD affecting his skin, intestines, and liver.
- The complex nature of this case highlights the need for careful diagnostics, including liver hemodynamic studies and biopsies, to distinguish between SOS and GVHD, as both conditions can severely impact patient outcomes.
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Vibrio vulnificus (V. vulnificus) is a gram-negative bacterium that can cause severe infections after entering the human body via open wounds or consumption of shellfish. An increased occurrence of bacteria is known at water temperatures > 20 °C.
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J Am Vet Med Assoc
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1Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY.
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