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| http://dx.doi.org/10.5021/ad.2013.25.3.382 | DOI Listing |
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Asymptomatic CD34 plaque on the scalp of a child.
J Cutan Pathol
October 2024
Sagis Diagnostics, Houston, Texas, USA.
Article Synopsis
- Fibroblastic connective tissue nevus (FCTN) is a rare, non-cancerous skin lesion derived from fibroblasts, which was identified in a 2-year-old boy with an unchanging red plaque on his scalp.
- A biopsy revealed abnormal growth patterns of fibroblastic cells, and although it tested positive for CD34 (which can indicate other conditions), further genetic testing ruled out a more aggressive tumor known as dermatofibrosarcoma protuberans.
- The case emphasizes the need for dermatologists and pathologists to accurately differentiate between various mesenchymal tumors, as they can have vastly different implications for treatment and management.
Update on Superficial Spindle Cell Mesenchymal Tumors in Children.
Dermatopathology (Basel)
July 2021
Department of Pathology, Necker-Enfants Malades Hospital, 75015 Paris, France.
Article Synopsis
- * Many rare tumors can be misdiagnosed due to their similarities, with new entities and genetic information providing crucial insights into these conditions over the last decade.
- * This review highlights key neoplasms such as fibroblastic connective tissue nevus and lipofibromatosis, emphasizing their histological and genetic similarities, which are important for accurate diagnosis and treatment strategies.
Medallion-like dermal dendrocyte hamartoma: A rare congenital CD34-positive dermal lesion clinically and pathologically overlapping with fibroblastic connective tissue nevus.
Pediatr Dermatol
May 2019
Department of Plastic and Reconstructive Surgery, Teikyo University Chiba Medical Center, Ichihara-shi, Chiba, Japan.
Both medallion-like dermal dendrocyte hamartoma and fibroblastic connective tissue nevus are rare benign dermal lesions composed of CD34-positive spindle cells. Although regarded as different diseases, it is sometimes difficult to distinguish between them due to their clinical and pathological similarities. We present a case of medallion-like dermal dendrocyte hamartoma that could also be diagnosed as fibroblastic connective tissue nevus and propose the possibility of overlap in these diseases.
View Article and Find Full Text PDFHypocellular medallion-like dermal dendrocyte hamartoma on the abdomen of a 25 year old male.
J Cutan Pathol
April 2019
Department of Dermatology, Philadelphia College of Osteopathic Medicine, Roswell, Georgia.
Medallion-like dermal dendrocyte hamartoma is a rare congenital lesion that is more commonly seen in females. It often presents at birth on the neck or upper trunk as a well-circumscribed, atrophic patch with wrinkling of the overlying skin. Clinically, the differential diagnosis includes atrophoderma, anetoderma, and congenital atrophic dermatofibrosarcoma protuberans.
View Article and Find Full Text PDFSolitary Fibrous Tumors in Pediatric Patients: A Rare and Potentially Overdiagnosed Neoplasm, Confirmed by STAT6 Immunohistochemistry.
Pediatr Dev Pathol
May 2019
1 Department of Pathology, Stanford University Medical Center, Stanford, California.
Pathological diagnosis of solitary fibrous tumor (SFT) in the pediatric population is challenging, as it occurs uncommonly in this age-group and resembles other spindle cell neoplasms. SFT contains a NAB2-STAT6 fusion gene, which can be reliably detected using STAT6 immunohistochemistry. Positive staining is highly sensitive and specific.
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