The study was performed on 22 patients with congenital heart valve defects after hypothermic cardiopulmonary bypass surgery. Transcutaneous and arterial pO2 and pCO2 have been measured at different stages of investigation. Nonpulsatile flow was applied to 10 patients and pulsatile flow--to 12 patients. Pulsatile pressure was maintained at about 30 mmHg. Transcutaneous index, carbon dioxide gradient and transcutaneous oxygen shunt have been calculated. Perfusion caused a decrease in transcutaneous pO2 and transcutaneous index, as well as an increase in transcutaneous O2 shunt. The use of non-pulsatile flow caused the most marked peripheral vasoconstriction. Transcutaneous index demonstrates that peripheral circulation decrease in pulsatile flow is 3 times lower than in non-pulsatile flow. Calculation of transcutaneous index and O2 shunt based on transcutaneous pO2 and pCO2 values can characterize peripheral circulation prior to, during and following perfusion.
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J Sleep Res
December 2024
Center for Investigation and Research in Sleep, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Central sleep apneas (CSA) can occur de novo at high-altitude in individuals without sleep-disordered breathing at low altitude. These apneas are usually brief, lasting only 5-15 s. This report presents the first documented case of a man experiencing extreme altitude-induced CSA lasting more than 100 s in the absence of any sleep breathing disorder in normoxia.
View Article and Find Full Text PDFCureus
September 2024
Anesthesiology, State University of New York Upstate Medical University, Syracuse, USA.
JAMA Netw Open
March 2024
Division of Endocrinology and Metabolic Diseases, University of Campania "Luigi Vanvitelli," Naples, Italy.
Importance: Peripheral artery disease (PAD) in diabetes may lead to diabetic foot ulcer and lower-extremities amputation. Glucagon-like peptide 1 receptor agonists have proven cardiovascular benefits in trials of people with type 2 diabetes at high cardiovascular risk.
Objective: To examine the effect of liraglutide on peripheral perfusion measured as peripheral transcutaneous oxygen pressure (TcPo2) in individuals with type 2 diabetes and PAD.
Magn Reson Med
July 2024
Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Haifa, Israel.
Purpose: Electron spin resonance (ESR) is used to measure oxygen partial pressure (pO) in biological media with many clinical applications. Traditional clinical ESR involves large magnets that encompass the subject of measurement. However, certain applications might benefit from a scanner operating within local static magnetic fields.
View Article and Find Full Text PDFACS Meas Sci Au
August 2023
Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.
In this article, we present a toolset to fully leverage a previously developed transcutaneous oxygenation monitor (TCOM) wearable technology to accurately measure skin oxygenation values. We describe numerical models and experimental characterization techniques that allow for the extraction of precise tissue oxygenation measurements. The numerical model is based on an inverse boundary problem of the parabolic equation with Dirichlet boundary conditions.
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