Herein we report the site-selective silylation of the ribonucelosides. The method enables a simple and efficient procedure for accessing suitably protected monomers for automated RNA synthesis. Switching to the opposite enantiomer of the catalyst allows for the selective silylation of the 3'-hydroxyl, which could be used in the synthesis of unnatural RNA or for the analoging of ribonucelosides. Lastly, the procedure was extended to ribavirin a potent antiviral therapeutic.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857215 | PMC |
| http://dx.doi.org/10.1021/ol402023c | DOI Listing |
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