The article discusses the issues of chemotherapeutical department organization and functioning in multidisciplinary surgical hospital. In connection with a worldwide spread of antibiotic-resistant agents of surgical infections, it becomes necessary to unite efforts of surgeons, resuscitation specialists, clinical pharmacologists - chemiotherapeutists and microbiologists. The main approaches in solving of surgical infection problems are: in-hospital epidemiological situation monitoring, the study ofmicroflora resistance to antibiotics used in the surgical and resuscitation practice, the study of antibacterial therapy clinical-pharmacological aspects (pharmacokinetics, pharmacodynamics, tolerance and efficacy of antimicrobial drugs). The development of pre-emptive antibiotics rotation principles curbs the spread ofnosocomial infections pathogens resistant strains. The 40-year experience of surgical infections prevention and treatment laboratory functioning professes this.
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