AI Article Synopsis
- - DNA demethylation plays a key role in turning on genes and is carried out by TET dioxygenases, particularly the TET3 protein.
- - The research focused on identifying a conserved nuclear localization signal (KKRK) within the TET3 protein that helps it move from the cytoplasm to the nucleus.
- - TET3's movement into the nucleus may also involve proteins called importin-α and importin-β, which assist in transporting it across the nuclear membrane.
Article Abstract
DNA demethylation is associated with gene activation and is mediated by a family of ten-eleven translocation (TET) dioxygenase. The TET3 protein is a 1668-amino-acid DNA demethylase that is predicted to possess five nuclear localization signals (NLSs). In this paper, we used a series of green fluorescent protein-tagged and mutation constructs to identify a conserved NLS (KKRK) embedded between amino acid 1615 and 1618 of mouse TET3. The KKRK sequence facilitates the cytoplasmic protein's translocation into the nucleus. Additionally TET3 may be imported into the nucleus by importin-α and importin-β.
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| http://dx.doi.org/10.1016/j.bbrc.2013.08.075 | DOI Listing |
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