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Microchip platforms for multiplex single-cell functional proteomics with applications to immunology and cancer research. | LitMetric

Microchip platforms for multiplex single-cell functional proteomics with applications to immunology and cancer research.

Genome Med

NanoSystems Biology Cancer Center, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

Published: June 2014

AI Article Synopsis

Article Abstract

Single-cell functional proteomics assays can connect genomic information to biological function through quantitative and multiplex protein measurements. Tools for single-cell proteomics have developed rapidly over the past 5 years and are providing approaches for directly elucidating phosphoprotein signaling networks in cancer cells or for capturing high-resolution snapshots of immune system function in patients with various disease conditions. We discuss advances in single-cell proteomics platforms, with an emphasis on microchip methods. These methods can provide a direct correlation of morphological, functional and molecular signatures at the single-cell level. We also provide examples of how those platforms are being applied to both fundamental biology and clinical studies, focusing on immune-system monitoring and phosphoprotein signaling networks in cancer.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978720PMC
http://dx.doi.org/10.1186/gm479DOI Listing

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