AI Article Synopsis
- A study investigated the effects of whole body X-irradiation on 4-week-old rats, focusing on cerebellar abnormalities caused by radiation exposure during embryonic development.
- Using high-resolution 3D T2-weighted MRI, researchers found that cerebellar volumes decreased in a dose-dependent manner as the radiation dose increased from 0.5 to 1.5 Gy.
- The analysis highlighted that the reduction in cerebellar size was primarily due to decreased cortical volume, with changes also observed in white matter and deep cerebellar nuclei, indicating prenatal X-irradiation leads to cerebellar cortical hypoplasia.
Article Abstract
Cerebellar abnormalities in 4-week-old rats with a single whole body X-irradiation at a dose of 0.5, 1.0, or 1.5 Gy on embryonic day (ED) 15 were examined by magnetic resonance imaging (MRI) volumetry. A 3D T2 W-MRI anatomical sequence with high-spatial resolution at 11.7-tesla was acquired from the fixed rat heads. By MRI volumetry, whole cerebellar volumes decreased dose-dependently. Multiple linear regression analysis revealed that the cortical volume (standardized β=0.901; P<0.001) was a major explanatory variable for the whole cerebellar volume, whereas both volumes of the white matter and deep cerebellar nuclei also decreased depending on the X-irradiation dose. The present MRI volumetric analysis revealed a dose-related cerebellar cortical hypoplasia by prenatal exposure to X-irradiation on E15.
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| http://dx.doi.org/10.1111/cga.12016 | DOI Listing |
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