AI Article Synopsis
- The study aimed to assess the toxic effects of Euphorbia hirta (E. hirta) on MCF-7 cancer cells using the comet assay for genotoxicity and brine shrimp lethality assay for cytotoxicity.
- Both tests revealed significant toxic effects, with E. hirta showing increased DNA damage in MCF-7 cells over time and a significant lethality rate in brine shrimp.
- The findings suggest E. hirta has cytotoxic and genotoxic properties, although further research is required to fully understand its toxicity profile.
Article Abstract
Objective: To evaluate the cytotoxicity and genotoxicity activity of Euphorbia hirta (E. hirta) in MCF-7 cell line model using comet assay.
Methods: The cytotoxicity of E. hirta extract was investigated by employing brine shrimp lethality assay and the genotoxicity of E. hirta was assessed by using Comet assay.
Results: Both toxicity tests exhibited significant toxicity result. In the comet assay, the E. hirta extract exhibited genotoxicity effects against MCF-7 DNA in a time-dependent manner by increasing mean percentage of DNA damage. The extract of E. hirta showed significant toxicity against brine shrimp with an LC₅₀ value of 620.382 µg/mL (24 h). Comparison with positive control potassium dichromate signifies that cytotoxicity exhibited by the methanol extract might have moderate activity.
Conclusion: The present work confirmed the cytotoxicity and genotoxicity of E. hirta. However, the observed toxicity of E. hirta extracts needs to be confirmed in additional studies.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757276 | PMC |
| http://dx.doi.org/10.1016/S2221-1691(13)60140-9 | DOI Listing |
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