A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 143

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 143
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 209
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 994
Function: getPubMedXML

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3134
Function: GetPubMedArticleOutput_2016

File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Serotonin2C Receptors and the Motor Control of Oral Activity. | LitMetric

Serotonin2C Receptors and the Motor Control of Oral Activity.

Curr Neuropharmacol

Université Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France ; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France.

Published: March 2013

AI Article Synopsis

  • Research shows that the serotonin2C (5-HT2C) receptor plays a significant role in regulating oral movements in rodents.
  • Both agonists and inverse agonists of this receptor can trigger purposeless oral movements, indicating its tight regulatory control on oral activity.
  • Chronic blockade of dopamine transmission increases the sensitivity of oral responses to 5-HT2C agonists, but the exact mechanisms behind this heightened sensitivity need further investigation, as 5-HT2C receptors may also be linked to abnormal motor behaviors in humans.

Article Abstract

Data from many experiments has shown that serotonin2C (5-HT2C) receptor plays a role in the control of orofacial activity in rodents. Purposeless oral movements can be elicited either by agonists or inverse agonists implying a tight control exerted by the receptor upon oral activity. The effects of agonists has been related to an action of these drugs in the subthalamic nucleus and the striatum, the two input structures for cortical efferents to the basal ganglia, a group of subcortical structures involved in the control of motor behaviors. The oral effects of agonists are dramatically enhanced in case of chronic blockade of central dopaminergic transmission induced by neuroleptics or massive destruction of dopamine neurons. The mechanisms involved in the hypersensitized oral responses to 5-HT2C agonists are not clear and deserve additional studies. Indeed, while the oral behavior triggered by 5-HT2C drugs would barely correspond to the dyskinesia observed in humans, the clinical data have consistently postulated that 5-HT2C receptors could be involved in these aberrant motor manifestations.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637670PMC
http://dx.doi.org/10.2174/1570159X11311020003DOI Listing

Publication Analysis

Top Keywords

oral activity
8
effects agonists
8
oral
6
agonists
5
serotonin2c receptors
4
receptors motor
4
control
4
motor control
4
control oral
4
activity data
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!