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| http://dx.doi.org/10.1177/003335491312800516 | DOI Listing |
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Background: Positive findings from testing therapeutics in AD animal models are often not translated to effective treatments due to the poor methodological rigor and inadequate reporting practices of therapeutic efficacy studies. The Alzheimer's Disease Preclinical Efficacy Database (AlzPED), developed by the NIA, is a searchable and publicly available knowledgebase that prioritizes and promotes the use of rigorous methodology to ameliorate this translation gap. Through a checklist of experimental design elements - the Rigor Report Card - AlzPED highlights reporting recommendations and standards while providing a practical tool to help plan rigorous therapeutic studies in animals.
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Alzheimers Dement
December 2024
Brigham and Women's Hospital and Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
The most recent Alzheimer's clinical trials, including those which reported successful outcomes, use neuroimaging biomarkers of both amyloid and tau for screening participants and demonstrating a treatment effect on pathology. Some of these trials, notably Lecanemab, hint at a potential sex bias in treatment outcome, alluding to major implications for clinical practice when recommending treatment options. Sex differences in treatment response are not surprising given that women are at greater risk of progression to AD dementia, particularly if they carry APOEe4.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Medical College of Georgia, Augusta, GA, USA.
Background: Alzheimer's disease poses significant global health challenges, particularly as people increasingly turn to online platforms for health information in the digital era. Given the intricate nature of Alzheimer's, it is imperative to evaluate the readability of online content. This study aims to assess the readability of information related to Alzheimer's disease on reputable health websites.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Medical College of Georgia, Augusta, GA, USA.
Background: Alzheimer's disease poses significant global health challenges, particularly as people increasingly turn to online platforms for health information in the digital era. Given the intricate nature of Alzheimer's, it is imperative to evaluate the readability of online content. This study aims to assess the readability of information related to Alzheimer's disease on reputable health websites.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
University of Chicago, Chicago, IL, USA.
Background: Primary progressive aphasia (PPA) is a dementia syndrome characterized by language and communication impairments, with relative sparing of other cognitive domains. As a relatively rare dementia syndrome, there are few measures developed and validated for individuals with PPA. Development of outcome measures tailored to the communication experiences of persons with PPA (PwPPA) is critical for the accurate assessment of interventions success.
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