The author investigated the frequency and character of side-effects to penicillin, levomycetin, tetracycline in the treatment of 92 patients with different forms of chronic bronchitis. Clinically all side-effects were subdivided in dysbacteriosis, allergic, toxic and mixed. It was established that the high incidence of side-effects furthers allergization of the body and potentiation of bronchial spasm. That is why the employment of antibiotics in these cases is not indicated. The low incidence of side-effect of antibiotics in purulent bronchitis requires their use under thorough medical surveillance.

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