The purpose of this study was to develop and test a novel and simple method for evaluating the disintegration time of rapidly disintegrating tablets (RDTs) in vitro, since the conventional disintegration test described in the pharmacopoeia produces poor results due to the difference of its environmental conditions from those of an actual oral cavity. Six RDTs prepared in our laboratory and 5 types of commercial RDTs were used as model formulations. Using our original apparatus, a good correlation was observed between in vivo and in vitro disintegration times by adjusting the height from which the solution was dropped to 8 cm and the weight of the load to 10 or 20 g. Properties of RDTs, such as the pattern of their disintegrating process, can be assessed by verifying the load. These findings confirmed that our proposed method for an in vitro disintegration test apparatus is an excellent one for estimating disintegration time and the disintegration profile of RDTs.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1248/cpb.c13-00441 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Designing a terahertz optical sensor based on helically twisted photonic crystal fiber for toxic gas sensing.
Sci Rep
January 2025
Department of Physics, Shiraz university of technology, Shiraz, Iran.
A novel helically twisted photonic crystal fiber (PCF) is designed and proposed for sensing toxic gases with refractive indices ranging from 1.00 to 1.08.
View Article and Find Full Text PDFIdentifying Key Weather Factors Influencing Human Salmonellosis: A Conditional Incidence Analysis in England, Wales, and the Netherlands.
J Infect
January 2025
School of Veterinary Medicine, University of Surrey, Daphne Jackson Rd, Guildford GU2 7AL, United Kingdom; The Surrey Institute for People-Centred Artificial Intelligence, Stag Hill University Campus, Guildford GU2 7XH, United Kingdom; Institute for Sustainability, University of Surrey, Guildford, United Kingdom; University of Exeter, Exeter, United Kingdom.
Objectives: This study aimed to improve the understanding of seasonal incidence pattern observed in salmonellosis by identifying the most influential weather factors, characterizing the nature of this association, and assessing whether it is geographically restricted or generalizable to other locations.
Methods: A novel statistical model was employed to estimate the incidence of salmonellosis conditional to various combinations of three simultaneous weather factors from 14 available. The analysis utilised daily salmonellosis cases reported from 2000 to 2016 along with detailed spatial and temporal weather data from England and Wales, and the Netherlands.
A novel Schirmer Strip-Based Tear Matrix Metalloproteinase Measurement in Dry Eye Evaluation.
Ocul Surf
January 2025
Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences; Key Laboratory of Ocular Fundus Diseases, Chinese Academy of Medical Sciences. Electronic address:
Unlabelled: Dry eye disease is a multifactorial disorder of the ocular surface with increasing global prevalence, yet no universally accepted "gold standard" exists for its diagnosis or severity assessment. Tear matrix metalloproteinase 9 (MMP-9) is widely recognized as a valuable biomarker for dry eye, yet there remains a critical need for a simple, accurate, and broadly applicable method for its quantification. This study aims to develop and evaluate a Schirmer strip-based Eu-time resolved fluorescence immunochromatography (Eu-TRFICO) method for the quantitative detection of MMP-9 in tears.
View Article and Find Full Text PDFA novel electronic nose for sensing (E)-2-hexenal based on Mn-MOF nanonets with NADPH-like activity.
Food Chem
January 2025
College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, China; University Key Laboratory of Food Processing Byproducts for Advanced Development and High Value Utilization, Xi'an 710119, China. Electronic address:
Bioreceptors are increasingly popular for selective aroma sensing but face challenges with receptor separation and cell culture. Here, we developed a bioreceptor-free electronic nose employing Mn-metal organic framework (Mn-MOF) nanonets as sensing materials for rapid electrochemical quantification of (E)-2-hexenal, a characteristic aroma commonly found in various foods. A simple solvent-mediated morphology engineering technology was proposed to create Mn-MOF structures, including nanoparticles, nanowires, and nanonets.
View Article and Find Full Text PDFPreparation and photoelectric properties of Si:B nanowires with thermal evaporation method.
PLoS One
January 2025
College of Physics and Electronic Engineering, Hainan Normal University, HaiKou, China.
We have successfully prepared a significant number of nanowires from non-toxic silicon sources. Compared to the SiO silicon source used in most other articles, our preparation method is much safer. It provides a simple and harmless new preparation method for the preparation of silicon nanowires.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!