Objective: The purpose of this study was to evaluate high-dose intravaginal metronidazole, with or without miconazole, in enhancing cure rates in women with recurrent BV.
Materials And Methods: A total of 43 women with symptomatic recurrent BV were enrolled in a 4-arm study comparing 500 mg versus 750 mg of metronidazole, with or without miconazole, intravaginally for 7 days. Test of cure by saline wet mount and 10% potassium chloride microscopy, pH, Gram stain for Nugent score, and yeast culture were performed 3 times after treatment: 3 to 7 days, 30 to 35 days, and 60 to 70 days.
Results: Overall cure rate for the entire group was 92.6% at visit 2, 62.1% at visit 3, and 51.4% at visit 4. At visit 2, there was no difference in cure rates among patients who received metronidazole 750 mg ± miconazole daily (90.5%) compared with metronidazole 500 mg ± miconazole daily (85%). At visit 3, there was a significant improvement in cure rates among patients who received metronidazole 750 mg ± miconazole daily (78.9%) compared with metronidazole 500 mg ± miconazole daily (44.4%) (p < .05). At visit 4, a significant difference in clinical cure rates persisted among patients who received metronidazole 750 mg ± miconazole daily (68.4%) compared with of metronidazole 500 mg ± miconazole daily (33.3%; p < .05). Poor responses (Nugent score > 4 or pH > 4.4) at the first visit alter treatment-predicted recurrence. The addition of miconazole did not enhance BV response rates.
Conclusions: Cure rates for BV were high in this refractory cohort and seemed dose dependent.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/LGT.0b013e31829a5558 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Efficacy of Plant Extract-Based Solutions Compared to Chlorhexidine and Miconazole Shampoo for the Treatment of Superficial Pyoderma in Dogs.
Vet Med Sci
January 2025
Centro Universitario UAEM Amecameca, Universidad Autónoma del Estado de México, Amecameca de Juárez, Estado de México, México.
Article Synopsis
- Canine superficial pyoderma (CSP) is a prevalent skin condition in dogs, and there's growing concern over antibiotic resistance, making natural remedies an appealing option.
- This study compares the effectiveness of natural topicals containing essential oils and plant extracts against a standard medicated shampoo with chlorhexidine and miconazole for treating CSP in thirty dogs.
- Results indicated that natural topicals significantly reduced skin lesions, pruritus, and bacterial counts more effectively than the medicated shampoo, suggesting they could be used alongside traditional treatments for CSP.
Efficacy of in the management of vulvovaginal candidiasis: comparative analysis with topical miconazole in a single-blind randomized clinical trial.
Front Microbiol
August 2024
Probiotical Research Srl, Novara, Italy.
Introduction: Vulvovaginal candidiasis (VVC) significantly impacts women's quality of life and often shows a high recurrence rate despite conventional antifungal therapies. This study evaluates the efficacy of (LF5), a probiotic, as an alternative treatment option to conventional miconazole therapy in managing VVC.
Methods: The randomized, single-blind clinical trial involved 100 premenopausal women diagnosed with VVC.
How effective is topical miconazole or amorolfine for mild to moderately severe onychomycosis in primary care: the Onycho Trial - a randomised double-blind placebo-controlled trial.
BMJ Open
May 2024
Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.
Objectives: To evaluate the efficacy of topical miconazole or amorolfine compared to placebo for mild to moderately severe onychomycosis.
Design: Randomised, double-blind, placebo-controlled trial, with computer-generated treatment allocation at a 1:1:1 ratio.
Setting: Primary care, recruitment from February 2020 to August 2022.
Mucoadhesive delivery systems for oral candidiasis treatment: A systematic review and meta-analysis.
Oral Dis
September 2024
Department of Prosthodontics and Periodontics, Bauru School of Dentistry, University of São Paulo (USP), Bauru, Brazil.
Objectives: This systematic review and meta-analysis aimed to evaluate the clinical and mycological effectiveness of mucoadhesives as vehicles for drugs or natural products in the treatment of oral candidiasis.
Materials And Methods: The search for articles was carried out in the Medline/PubMed, SCOPUS, EMBASE, Web of Science, Cochrane Library, and SciELO databases before August 2023. We selected the studies, extracted the data, evaluated the study quality, graded the evidence, performed the risk of bias, and carried out meta-analysis.
Zoonotic Majocchi's Granuloma of the Vulva.
Skinmed
March 2024
Cooper Medical School of Rowan University, 401 Broadway St, Camden, NJ;
Article Synopsis
- - A 32-year-old woman experienced itchy, painful skin lesions in the vulva and on her shins for 2 months, initially treated with corticosteroids and vancomycin without success.
- - Biopsies revealed Majocchi's granuloma, an infection caused by fungal infiltration in hair follicles, confirmed through growth in tissue culture and further analysis; the patient had recently adopted a guinea pig with similar skin issues.
- - After being prescribed terbinafine and ketoconazole cream, she showed significant improvement, and after 6 months of treatment, her skin remained clear for 4 months after stopping antifungals; her guinea pig was also treated successfully by a veterinarian.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!