AI Article Synopsis
- The NAIP gene is linked to preventing cell death (apoptosis) and inflammation, but how it is expressed is not well understood.
- Research shows that the TEA domain protein 1 (TEAD1) can activate the NAIP gene's expression, but it needs to interact with another protein called YAP.
- A specific region within the NAIP gene responds to the TEAD1/YAP interaction, indicating that this regulation happens during the gene's transcription process.
Article Abstract
Although the expression of the neuronal apoptosis inhibitory protein (NAIP) gene is considered involved in apoptosis suppression as well as in inflammatory response, the molecular basis of the NAIP gene expression is poorly understood. Here we show that the TEA domain protein 1 (TEAD1) is able to positively activate the transcription of NAIP. We further demonstrate that this regulation is mediated by the presence of the endogenous Yes associated protein (YAP) cofactor, and requires the interaction with YAP. We finally identified an intronic region of the NAIP gene responding to TEAD1/YAP activity, suggesting that regulation of NAIP by TEAD1/YAP is at the transcriptional level.
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| http://dx.doi.org/10.1016/j.febslet.2013.08.013 | DOI Listing |
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