Thio-dimethylarsinic acid (thio-DMA(V)) has recently been identified as human metabolite after exposure toward both the human carcinogen inorganic arsenic and arsenosugars, which are the major arsenical constituents of marine algae. This study aims to get further insight in the toxic modes of action of thio-DMA(V) in cultured human urothelial cells. Among others effects of thio-DMA(V) on eight cell death related endpoints, cell cycle distribution, genotoxicity, cellular bioavailability as well as for the first time its impact on DNA damage induced poly(ADP-ribosyl)ation were investigated and compared to effects induced by arsenite. The data indicate that thio-DMA(V) exerts its cellular toxicity in a similar or even lower concentration range, however most likely via different mechanisms, than arsenite. Most interestingly, thio-DMA(V) decreased damage-induced cellular poly(ADP-ribosyl)ation by 35,000-fold lower concentrations than arsenite. The inhibition of this essential DNA-damage induced and DNA-repair related signaling reaction might contribute to inorganic arsenic induced toxicity, at least in the bladder. Therefore, and also because thio-DMA(V) is to date by far the most toxic human metabolite identified after arsenosugar intake, thio-DMA(V) should contemporary be fully (also in vivo) toxicologically characterized, to assess risks to human health related to inorganic arsenic but especially arsenosugar dietary intake.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jtemb.2013.06.004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Feasible approaches for arsenic speciation analysis in foods for dietary exposure assessment: a review.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess
January 2025
Department of Food Science and Nutrition, Hong Kong Polytechnic University, Kowloon, Hong Kong, China.
Arsenic (As) occurs naturally in different forms and oxidation states. Amongst them, inorganic arsenic (iAs) is classified as both genotoxic and carcinogenic whilst other organic arsenic species are considered less toxic. As in rice is mainly present in the form of iAs which therefore poses a health risk to populations that consume rice as a staple food.
View Article and Find Full Text PDFDisentangling the role of selenium in antagonizing the toxicity of arsenic and cadmium.
Arch Toxicol
January 2025
Department of Biomedicine and Environmental Research, Faculty of Medicine, Institute of Biological Sciences, The John Paul II Catholic University of Lublin, Konstantynów Ave. 1J, 20-708, Lublin, Poland.
Cadmium (Cd) and inorganic arsenic (As) compounds are considered to be among the major public health hazards. This is due to both the high intrinsic toxicity of these substances and the often difficult to avoid exposure of the general population through contaminated water and food. One proposed method to reduce the toxic effects of As and Cd on animals and humans is the use of selenium (Se).
View Article and Find Full Text PDFSynthesis and Redox Chemistry of Co3E4 (E = P, As) Clusters.
Chemistry
January 2025
University of Regensburg, Inorganic Chemistry, Universitätsstrasse 31, D-93040, Regensburg, GERMANY.
The synthesis of the cluster complexes [(Cp'''Co)3(µ3,η2:η2:η2-E3)(µ3-E)] (E = P (3), As (4)) starting from the anionic triple-decker complexes [K(18cr6)(dme)2][(Cp'''Co)2(µ,η4:η4-E4)]- (E = P (1), As (2)) by electrophilic quenching with the Co dimer [(Cp'''CoCl)2] is reported. Both complexes show a distinct redox chemistry, which was first investigated by cyclic voltammetry. Subsequently, the monoanions [K(L)(sol)n][(Cp'''Co)3(µ3,η2:η2:η2-E3)(µ3-E)] (E = P, L = 18cr6, sol = dme, n = 2 (5), E = As, L = 2,2,2-crypt, n = 0 (6)), the monocations [(Cp'''Co)3(µ3,η2:η2:η2-E3)(µ3-E)][FAl] (E = P (7), As (8)) and the dications [(Cp'''Co)3(µ3,η3:η3:η3-E4)][TEF]2 (E = P (9), As (10)) could be realized experimentally and isolated in moderate to good yields.
View Article and Find Full Text PDFStructure-Optical Properties Relationships in Cobalt-Based Purple Pigments Used by Robert Delaunay.
J Am Chem Soc
January 2025
Université Paris-Saclay, ENS Paris-Saclay, CNRS, PPSM, 91190 Gif-sur-Yvette, France.
Following the industrial revolution and the modernization of chemistry, purple became one of the most popular colors in the palettes of late 19th- to 20th-century painters. Among them, Robert Delaunay (1885-1941) was one of the key artists of the avant-garde movement in France in the early 20th century. Although widely used in modern and contemporary paintings, inorganic purple pigments of the cobalt phosphate and cobalt arsenate families have been little studied chemically until now.
View Article and Find Full Text PDFSodium arsenite induces islets β-cells apoptosis and dysfunction via SET-Rac1-mediated cytoskeleton disturbance.
Ecotoxicol Environ Saf
January 2025
Department of Occupational and Environmental Health, School of Public Health, Dalian Medical University, No. 9 West Section Lvshun South Road, Dalian 116044, China; Global Health Research Center, Dalian Medical University, No. 9 West Section Lvshun South Road, Dalian 116044, China. Electronic address:
Sodium arsenite (NaAsO), the most common form of inorganic arsenic prevalent in the environment, has been closely linked to islet β-cell dysfunction, a critical pathological hallmark of type 2 diabetes (T2D). Even though apoptosis plays a pivotal role in arsenic-induced islet β-cell dysfunction, the explicit underlying mechanisms remain elusive. Here, we have identified that the SET-Rac1 signaling pathway is instrumental in the apoptosis and dysfunction of islet β-cells induced by NaAsO.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!