Unlabelled: Objective To evaluate an automated method that extracts motor unit (MU) information from the CMAP scan, a high-detail stimulus-response curve recorded with surface EMG. Discontinuities in the CMAP scan are hypothesized to result from MU loss and reinnervation.
Methods: We introduce the parameter D50 to quantify CMAP scan discontinuities. D50 was compared with a previously developed manual score in 253 CMAP scans and with a simultaneously obtained motor unit number estimate (MUNE) in 173 CMAP scans. The effect of MU loss on D50 was determined with a simulation model.
Results: We found a high agreement (sensitivity=86.8%, specificity=96.6%) between D50 and the manual score. D50 and MUNE were significantly correlated below 80 MUs (r=0.65, n=68, p<0.001), but not when MUNE was larger than 120 MUs (r=0.23, n=59, p=0.08).
Conclusions: Discontinuities in the CMAP scan as expressed by a decreased D50 are related to significant MU loss. The determination of D50 is objective, quantitative, and less time-consuming than both manual scoring and many existing MUNE methods.
Significance: D50 is potentially useful to monitor neurogenic disorders and moderate to severe MU loss.
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