AI Article Synopsis
- - Grape seed extracts (GSEs) exhibited both antioxidant and pro-oxidant activities in yeast cells with different antioxidant system defects, showing varying effects on cellular growth and recovery from hydrogen peroxide damage.
- - In prostate cancer PC3 and HBV-replicating HepG2 2.2.15 cells, red grape seed extract (RW) demonstrated higher cytotoxicity compared to white grape seed extract (WW), which depended on the dosage and duration of treatment.
- - Despite their cytotoxic effects, GSEs did not exhibit any antiviral activity against hepatitis B virus (HBV) in treated HepG2 2.2.15 cells, highlighting their selective action based on the cellular context.
Article Abstract
Grape seed extracts (GSEs) were investigated in yeast cells harbouring defects in their antioxidant system (regarding the cellular growth and growth recovery from H2O2 insult). GSEs antioxidant activity was detected in wild-type and mutant strains Δcta1, Δgsh1 and Δoye2glr1, while pro-oxidant activity in Δsod1 cells was seen. Assessment of proliferation of prostate cancer PC3 and HBV-replicating HepG2 2.2.15 cells treated with GSEs has shown higher cytotoxicity of red grape seed extract (RW) than white grape seed extract (WW) subjective to dose and period of administration. No antiviral effect was detected by measuring the secreted virion particles in HepG2 2.2.15 cells treated with GSEs. The GSEs play a dual antioxidant/pro-oxidant role in vivo according with the cellular antioxidant system deficiencies and exhibit cytotoxic properties in PC3 and HepG2 2.2.15 cell lines, but no antiviral action against HBV.
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| http://dx.doi.org/10.1016/j.foodchem.2013.06.094 | DOI Listing |
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