AI Article Synopsis
- Closantel is a veterinary drug effective against liver fluke in cattle and sheep, with a maximum residue limit (MRL) of 45 μg/kg set in EU milk.
- Following treatment, milk from dry cows showed lower closantel residues compared to lactating cows, with levels exceeding the MRL detected for up to 198 days.
- Residues were found to concentrate in dairy products like cheese, butter, and skim milk powder, suggesting dry-cow treatment is preferable for minimizing residue risk in milk.
Article Abstract
Closantel is a veterinary drug used to treat liver fluke in cattle and sheep. A provisional maximum residue limit (MRL) of 45 μg/kg in milk has been set by the European Union. The purpose of this study was to investigate the persistence of closantel residues in milk and the migration of residues into milk products. Following dry-cow treatment, residues ranged from undetectable to 8.7 μg/kg at the first milking. Following lactating-cow treatment, residues detected ranged from 278 to 482 μg/kg at day 1 post-treatment and were detectable above the MRL for 52 days and detectable for 198 days. At day 2 and day 23 post-treatment, the milk was collected and dairy products manufactured. Closantel residues concentrated in the cheese, butter, and skim milk powder. The results indicate that closantel is best used as a dry-cow treatment.
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