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Oxidative byproducts of cannabidiol (CBD) are known to be cytotoxic. However, CBD susceptibility to oxidation and resulting toxicity dissolved in two common solvents, ethanol (EtOH) and dimethyl sulfoxide (DMSO), is seldom discussed. Furthermore, CBD products contain a wide range of concentrations, making it challenging to link general health risks associated with CBD cytotoxicity.
View Article and Find Full Text PDFInvestigations on the effects of in vitro exposure of mouse ovaries to withaferin A, a new candidate for chemotherapy.
Reprod Toxicol
January 2025
Faculty of Veterinary Medicine, Laboratory of Manipulation of Oocyte and Ovarian Preantral Follicles (LAMOFOPA), State University of Ceará, Av. Dr. Silas Munguba, 1700, CEP: 60714-903, Fortaleza, CE, Brazil. Electronic address:
This study aimed to investigate, in vitro, the toxicity of WTA on ovarian follicles. Initially, a cytotoxicity assay was conducted using tumor and non-tumor cell lines to determine the ICof the WTA and validate its antitumor activity. Mouse ovaries were cultured in vitro (IVC) for 6 days in the presence of 1% dimethyl sulfoxide (DMSO), doxorubicin at 0.
View Article and Find Full Text PDFPreparation of ,-[Pt(py)(N)(OH)] via Photoinduced Reactivity of [Pt(NO)] Anion.
Inorg Chem
January 2025
Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Science, 630090 Novosibirsk, Russia.
The photoinduced reaction of [Pt(NO)] with pyridine or its derivatives (L) was found to result in the formation of [PtL](NO) salts in high yield. This transformation was successfully probed for methyl- and carboxyethyl-substituted pyridines, and the corresponding [PtL](NO) salts were isolated and fully characterized using single-crystal X-ray diffraction (SCXRD). Anation of the [Pt(py)] cationic complex with N was studied by H NMR spectroscopy in aqueous and water/dimethyl sulfoxide solutions of [Pt(py)](NO).
View Article and Find Full Text PDFJoint exploration of network pharmacology and metabolomics on the effects of traditional Chinese medicine compounds in weaned yaks.
Front Vet Sci
January 2025
College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Introduction: Chinese herbal medicines are relatively inexpensive and have fewer side effects, making them an effective option for improving health and treating diseases. As a result, they have gained more attention in recent years. The weaning period is a critical stage in the life of yaks, often inducing stress in calves.
View Article and Find Full Text PDFCrystallization of CsPbBr Nanocrystals within a Melt-Quenched Glassy Coordination Polymer.
ACS Nano
January 2025
Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education, LIFM, GBRCE for Functional Molecular Engineering, School of Chemistry, IGCME, Sun Yat-Sen University, Guangzhou 510275, China.
Lead halide perovskite nanocrystal materials such as CsPbX (X = Cl, Br, and I) have triggered an intense research upsurge due to their excellent scintillation performance. Herein, an crystallization strategy is developed to grow CsPbBr nanocrystals (NCs) within a low-melting-point (280 °C) coordination polymer (CP) glass. The viscosity of coordination glass is reduced through a low-temperature (e.
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