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Assessing the efficacy of polyvinyl alcohol/chitosan nanofibrous mat loaded with myrtle essential oil/gum Arabic in wound healing.
J Biomater Sci Polym Ed
March 2025
Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran.
Nowadays, extensive research has been conducted on electrospun nanofibers for wound dressing applications. Considering the growing concern over bacterial resistance to common antibiotics, investigating the potential of natural essential oils with antibacterial properties could prove to be beneficial in addressing this issue. In response to the challenges posed by impaired wound healing, we have designed a novel electrospun polyvinyl alcohol/chitosan nanofiber embedded with myrtle essential oil and gum Arabic dispersion (PVA/CS/MT-GA).
View Article and Find Full Text PDF[Fever and Pancytopenia - not Always a Case for Oncology].
Praxis (Bern 1994)
February 2025
Klinik für Innere Medizin, Stadtspital Zürich.
The article describes the case of a 68-year-old patient who was admitted to a clinic after returning from southern Italy with fever, night sweats, and pancytopenia. After extensive diagnostic investigations that ruled out bacterial, viral, and parasitic infections as well as other diseases, visceral leishmaniasis (VL) were eventually diagnosed. This diagnosis was confirmed by the detection of Leishmania sp.
View Article and Find Full Text PDFExploring the repository of de novo-designed bifunctional antimicrobial peptides through deep learning.
Elife
March 2025
Frontiers Science Center for Synthetic Biology (Ministry of Education), Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Faculty of Medicine, Tianjin University, Tianjin, China.
Antimicrobial peptides (AMPs) are attractive candidates to combat antibiotic resistance for their capability to target biomembranes and restrict a wide range of pathogens. It is a daunting challenge to discover novel AMPs due to their sparse distributions in a vast peptide universe, especially for peptides that demonstrate potencies for both bacterial membranes and viral envelopes. Here, we establish a de novo AMP design framework by bridging a deep generative module and a graph-encoding activity regressor.
View Article and Find Full Text PDFMonte Carlo simulation to optimize polymyxin B dosing regimens for the treatment of Gram-negative bacteremia.
Front Cell Infect Microbiol
March 2025
Department of Pharmacy, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, Shandong, China.
Objective: This study aimed to predict and evaluate the efficacy of various polymyxin B dosing regimens for Gram-negative bacteremia using Monte Carlo simulation, with a specific focus on assessing the efficacy in patients receiving continuous renal replacement therapy (CRRT). The goal was to optimize clinical dosing regimens and guide rational polymyxin B use in practice.
Methods: A total of 1,939 Gram-negative bacterial strains were analyzed, collected between April 2019 and December 2021 through the China Bloodstream Gram-negative Pathogens Antimicrobial Resistance and Virulence Surveillance Network (CARVIS-NET).
Establishment and validation of a dual qPCR method for the detection of carbapenem-resistant in bloodstream infections.
Front Cell Infect Microbiol
March 2025
Department of Clinical Laboratory, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Laboratory, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Objective: Bloodstream infections(BSIs) caused by carbapenem-resistant (CRAB) have a high mortality rate due to the high levels of drug resistance. There is an urgent need to establish a sensitive and accurate detection method to rapidly detect CRAB in BSIs.
Methods: A new method was developed based on fluorescence quantitative PCR (qPCR) targeting the specific region of 16sRNA and OXA-23 gene from CRAB.
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