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Exploring the fate of 6PPD in zebrafish (Danio rerio): Understanding toxicokinetics, biotransformation mechanisms, and metabolomic profiling at environmentally relevant levels.
J Hazard Mater
February 2025
Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China. Electronic address:
In recent years, N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) has attracted significant attention in environmental science, yet its behavior in biological systems remains poorly understood. This study involved a 28-day zebrafish exposure experiment at three concentrations (2, 20, and 200 μg/L), to investigate its physiologically based toxicokinetic (PBTK) properties, the formation of biotransformation products, and the metabolic characteristics of liver tissue. The results indicated that the liver and intestines are key organs for 6PPD accumulation, with tissue-specific distribution patterns.
View Article and Find Full Text PDFClay-catalyzed ozonation of Norfloxacin - Effects of metal cation and degradation rate on aqueous media toxicity towards Lemna minor.
Chemosphere
March 2025
Nanoqam, Department of Chemistry, University of Quebec at Montreal, H3C 3P8, Canada; École de technologie supérieure, Montréal, Québec, H3C 1K3, Canada. Electronic address:
Article Synopsis
- Norfloxacin was ozonized in clay suspensions to study its toxicity on Lemna minor, which helps assess antibiotic impact in environments with clay.
- The study found that norfloxacin causes toxicity in Lemna minor through oxidative stress, worsened by ozonation, affecting growth and chlorophyll levels.
- Results indicate that the type of clay catalyst and the oxidation process influence the toxicity outcomes, revealing the potential formation of more harmful byproducts from the antibiotic.
Degradation kinetics, pathways, transformation products, and toxicity assessment of fluorochloridone in agricultural soils.
Ecotoxicol Environ Saf
January 2025
Academy of Agriculture and Forestry, Qinghai University, 251 Ningda Road, Chengbei District, Xining City, Qinghai Province 810016, China; Key Laboratory of Agricultural Integrated Pest Management, Qinghai academy of agriculture and forestry, 253 Ningda Road, Chengbei District, Xining City, Qinghai Province 810016, China. Electronic address:
Flurochloridone (FLC) is a pyrrolidone herbicide used to control broad-leaved weeds in various crop fields. However, there is still a lack of comprehensive research on the environmental fate of the Qinghai-Tibet Plateau (QTP) and the toxicity of its potential transformation products (TPs). In this study, laboratory experiments were conducted to investigate the degradation kinetics, pathways, and toxicity of FLC's TPs.
View Article and Find Full Text PDFMultifunctional System with Camptothecin and [12]aneN Units for Effective Anti Pancreatic Cancer through Synergistic Chemotherapy, Gene Therapy, and Photodynamic Therapy.
ACS Appl Mater Interfaces
December 2024
China National Institute for Food and Drug Control, Institute of Chemical Drug Control, HuaTuo Road 29, Beijing 100050, China.
Maximizing drug cargo carrying capacity in blood circulation, controlling the fate of nanoparticles, and precisely drug release to tumor targets are the main aims of multifunctional nanomedicine-based antitumor therapy. Here we combined macrocyclic polyamine di(triazole-[12]aneN) () and chemical drug camptothecin (CPT, ) through photosensitizer 1,1-dicyano-2-phenyl-2-(4-diphenylamino) phenyl-ethylene () containing the cleavable disulfide () linkage as an all-in-one theranostic nanoprodrug, . The corresponding compound with carbon chain () linkage, , was also prepared for a comparison study.
View Article and Find Full Text PDFDevelopment of a straightforward direct injection UHPLC-MS/MS method for quantification of plastic additive chemicals in roadside retention ponds.
Anal Bioanal Chem
January 2025
School of Pharmacy, Applied Sciences and Public Health, Robert Gordon University, Aberdeen, AB10 7GJ, UK.
There is growing interest in road pollution that enters surface waters. Additive chemicals used in the manufacture of plastics, including tyre rubber, are mobile pollutants that pose a threat to aquatic life. Therefore, an ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method was developed to measure 25 plastic additive chemicals in road runoff and water of retention ponds used to manage road runoff.
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