The Anopheles innate immune system in the defense against malaria infection.

J Innate Immun

W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Md., USA.

Published: November 2015

The multifaceted innate immune system of insects is capable of fighting infection by a variety of pathogens including those causing human malaria. Malaria transmission by the Anopheles mosquito depends on the Plasmodium parasite's successful completion of its lifecycle in the insect vector, a process that involves interactions with several tissues and cell types as well as with the mosquito's innate immune system. This review will discuss our current understanding of the Anopheles mosquito's innate immune responses against the malaria parasite Plasmodium and the influence of the insect's intestinal microbiota on parasite infection.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939431PMC
http://dx.doi.org/10.1159/000353602DOI Listing

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