AI Article Synopsis
- A copolymer of locust bean gum was created using microwave irradiation with ceric ammonium nitrate as an initiator, optimizing factors like irradiation time and initiator amount.
- The resulting grafted gum was extensively characterized using techniques such as FT-IR, NMR, SEM, and others, confirming its biodegradability and non-toxic properties.
- It was then utilized to make controlled-release matrix tablets for buflomedil hydrochloride, showing a drug release profile comparable to hydroxypropyl methylcellulose.
Article Abstract
Acrylamide grafted copolymer of locust bean gum was prepared by microwave irradiation using ceric ammonium nitrate as redox initiator. The grafting process was optimized in terms of irradiation time, amount of initiator and acrylamide by using constant amount of native locust bean gum. The grafted gum was characterized by Fourier transform infrared spectroscopy (FT-IR), (13)C nuclear magnetic resonance (NMR), scanning electron microscopy (SEM), X-ray diffraction study (XRD), differential scanning calorimetry (DSC), elemental analysis, contact angle, viscosity, molecular weight, swelling and biodegradability studies. The grafted gum was found to be biodegradable and non-toxic. It was further used to prepare controlled-release matrix tablet of buflomedil hydrochloride. The in vitro release profile of the tablet showed the rate controlling property of acrylamide grafted locust bean gum was similar to that of hydroxypropyl methylcellulose (HPMC-K15M).
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| http://dx.doi.org/10.1016/j.carbpol.2013.07.037 | DOI Listing |
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