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Membrane destabilization by monomeric hIAPP observed by imaging fluorescence correlation spectroscopy. | LitMetric

Membrane destabilization by monomeric hIAPP observed by imaging fluorescence correlation spectroscopy.

Chem Commun (Camb)

Departments of Biological Sciences and Chemistry and NUS Centre for Bio-Imaging Sciences (CBIS), National University of Singapore, 117557, Singapore.

Published: October 2013

AI Article Synopsis

Article Abstract

Monomeric hIAPP significantly destabilizes both model and live cell membranes by increasing membrane fluidity. This interaction with membranes happens via carpet formation followed by lipid extraction in a concentration dependent manner and thus we propose that hIAPP aggregation prior to membrane interaction may not be necessary for its cytotoxicity.

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Source
http://dx.doi.org/10.1039/c3cc44880kDOI Listing

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