AI Article Synopsis
- Hyperglycemia may lead to apoptosis, and TRAIL has been connected to diabetes, particularly in type 2 diabetic nephropathy patients with foot disease.
- Twenty-two patients with diabetic nephropathy and foot ulcers were studied, examining their serum-soluble TRAIL and hs-CRP levels against healthy controls.
- Results showed that patients had lower sTRAIL levels and that hs-CRP was linked to age and other health metrics, indicating that TRAIL may have a protective function in these patients.
Article Abstract
Background: Hyperglycemia is among the potent factors that may induce or facilitate apoptosis. TNF-Related Apoptosis-Inducing Factor (TRAIL) is known for its apoptotic and immunomodulatory effects that have recently been correlated with diabetes. We examined serum-soluble TRAIL (sTRAIL) and high-sensitivity CRP (hs-CRP) levels and their association with various distinct parameters in type 2 diabetic nephropathy patients with diabetic foot disease.
Material/methods: Twenty-two diabetic nephropathy patients with foot ulcers were enrolled in our study. Patients had been diagnosed with diabetes at age 24±10.58 years. Circulating sTRAIL and Hs-CRP levels were compared with control values, and possible correlations were investigated with parameters such as age, Wagner's Grade (WG), BMI, HbA1c, and creatinine.
Results: Serum sTRAIL levels were significantly reduced in the patient group, compared to healthy subjects. High HsCRP levels correlated with age, and WGS correlated with BMI and creatinine levels.
Conclusions: Significantly suppressed sTRAIL levels in diabetic nephropathy patients with foot ulcers compared to healthy controls suggest a protective role for TRAIL in the disease setting.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762395 | PMC |
| http://dx.doi.org/10.12659/MSM.889514 | DOI Listing |
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