AI Article Synopsis
- MicroRNAs are known to control over 60% of protein-coding genes by inhibiting or degrading their mRNAs through AGO2 complexes in the cytoplasm.
- Recent research highlights that microRNA-9 (miR-9) specifically regulates the long non-coding RNA MALAT-1, which is significant and widely conserved.
- This study uncovers a new direct regulation between microRNAs and long non-coding RNAs, enhancing our understanding of microRNA roles beyond just protein coding.
Article Abstract
microRNAs regulate the expression of over 60% of protein coding genes by targeting their mRNAs to AGO2-containing complexes in the cytoplasm and promoting their translational inhibition and/or degradation. There is little evidence so far for microRNA-mediated regulation of other classes of non-coding RNAs. Here we report that microRNA-9 (miR-9) regulates the expression of the Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT-1), one of the most abundant and conserved long non-coding RNAs. Intriguingly, we find that miR-9 targets AGO2-mediated regulation of MALAT1 in the nucleus. Our findings reveal a novel direct regulatory link between two important classes of non-coding RNAs, miRs and lncRNAs, and advance our understanding of microRNA functions.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756333 | PMC |
| http://dx.doi.org/10.1038/srep02535 | DOI Listing |
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