Brain lesions related to pregnancy are not frequent, but are potentially lethal. About half of the cases are intracerebral hemorrhage, subarachnoid hemorrhage, infarction, and venous thrombosis. Their imaging characteristics are not much different from those caused by other reasons than pregnancy, and can be relatively easily recognized. The other half of cases are encephalopathy related to pregnancy-induced hypertension, eclampsia, and other factors. Such pregnancy-related vascular encephalopathy can be grossly sorted into 3 categories: posterior reversible encephalopathy syndrome, HELLP (hemolysis-elevated liver enzymes-low platelets) syndrome, and reversible cerebral vasoconstriction syndrome. These conditions are rare, but neurosurgeons must be able to recognize them.
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http://dx.doi.org/10.2176/nmc.53.520 | DOI Listing |
Neurosurg Rev
January 2025
Department of Neurosurgery, Sana Kliniken Duisburg, Academic Teaching Hospital of University Duisburg-Essen, Duisburg, Germany.
Pineal gland lesions pose a significant surgical challenge due to the deep-seated nature of the pineal gland, as well as the limited field of view, and the complex vascular anatomy. The mainstay of surgical treatment, when necessary, is always histopathological clarity and gross total resection (GTR). We evaluate the surgical outcomes for pineal gland lesions, shedding light on functional outcomes, histological findings, and surgical complications.
View Article and Find Full Text PDFNeurosurg Rev
January 2025
Department of Neurosurgery, Pamukkale University School of Medicine, Kim Burchiel Gamma Knife Center, Denizli, Türkiye, Turkey.
This study aims to demonstrate the effect of gamma knife radiosurgery (GKRS) on symptoms, hemorrhage rates, and histopathological changes in patients with cavernous malformations (CMs), regardless of whether the symptomatic lesions are hemorrhagic. This single-center retrospective study evaluated symptomatic patients with single CMs treated with GKRS between 2016 and 2023. The patients' demographic data, presenting symptoms, GKRS radiation dose, complications developed during follow-up (hemorrhage, radiotoxicity), the rate of symptom improvement, and histopathological changes of surgically removed CMs were recorded.
View Article and Find Full Text PDFMonaldi Arch Chest Dis
January 2025
Department of Cardiology, Izmir City Hospital, Izmir.
High blood levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) have been shown in various malignancies. In lung cancer, the importance of NT-proBNP is not clear. In this study, we aimed to investigate the significance of the correlation of NT-proBNP levels in lung cancer with tumor stage, tumor diameter, histopathology, and specific sites of mediastinal metastasis: lymphadenopathy; pericardial, cardiac, major vessel, other mediastinal organ or lymphatic involvement/invasion.
View Article and Find Full Text PDFAlzheimer Dis Assoc Disord
January 2025
Department of Neurology, Emory U, GA.
Introduction: We previously followed Emory patients with neurodegenerative disease from 1993 to 2006. Here, we follow survivor and new patients for 2007 to 2018.
Methods: We studied mortality from 10 different diagnostic groups among 4322 research volunteers, and compared mortality rates to controls with normal cognition, using Cox regression.
Commun Biol
January 2025
School of Psychology and Sussex Neuroscience, University of Sussex, Brighton, UK.
Reduced cerebral blood flow occurs early in the development of Alzheimer's disease (AD), but the factors producing this reduction are unknown. Here, we ask whether genetic and lifestyle risk factors for AD-the ε4 allele of the Apolipoprotein (APOE) gene, and physical activity-can together produce this reduction in cerebral blood flow which leads eventually to AD. Using in vivo two-photon microscopy and haemodynamic measures, we record neurovascular function from the visual cortex of physically active or sedentary mice expressing APOE3 and APOE4 in place of murine APOE.
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