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Nongenetic risk factors for thyroid cancer: an umbrella review of evidence.
Endocrine
January 2025
Division of Endocrinology and Metabolism, Laboratory of Diabetes and Metabolism Research, West China Hospital, Sichuan University, Chengdu, China.
Background: The incidence of thyroid cancer has increased annually, but the risk factors for thyroid cancer are still unclear. In this umbrella review, we aimed to identify associations between nongenetic risk factors and thyroid cancer incidence, and assess the quality and validity of the evidence.
Methods: PubMed, Embase and the Cochrane Database of Systematic Reviews were searched to identify related meta-analyses or systematic reviews of epidemiological studies.
Racial/ethnic differences in risk factors for non-cardia gastric cancer: an analysis of the Multiethnic Cohort (MEC) Study.
Cancer Causes Control
November 2024
Division of Surgical Oncology, Rutgers Cancer Institute, New Brunswick, NJ, USA.
Purpose: Gastric cancer (GC) incidence rates show notable differences by racial/ethnic groups in the US. We sought to determine whether stratification by race/ethnicity would reveal unique risk factors for development of non-cardia gastric cancer (NCGC) for US population.
Methods: Analysis included 1,112 incident cases of NCGC and 190,883 controls from the Multiethnic Cohort Study, a prospective US cohort study that recruited individuals living in Hawaii and California, aged 45-75 years from 5 races/ethnicities.
Unraveling the potential effects of non-synonymous single nucleotide polymorphisms (nsSNPs) on the Protein structure and function of the human gene on type 2 diabetes and colorectal cancer: An approach.
Heliyon
September 2024
Department of Computer Engineering, Umm Al-Qura University, Mecca 24381, Saudi Arabia.
Background And Aims: The single nucleotide polymorphisms (SNPs) in gene have been recognized as contributing to type 2 diabetes (T2D) susceptibility and colorectal cancer. This study aims to predict the structural stability, and functional impacts on variations in non-synonymous SNPs (nsSNPs) in the human gene using various computational techniques.
Materials And Methods: Several tools, including SIFT, Predict-SNP, SNPs&GO, MAPP, SNAP2, PhD-SNP, PANTHER, PolyPhen-1,PolyPhen-2, I-Mutant 2.
Robotic colectomy has been associated with comparable or improved short-term morbidity and mortality when compared to laparoscopic colectomy, including shorter length of stay. In this study, we sought to understand oncologic advantages for robotic as compared to laparoscopic colectomy in colon cancer. We analyzed the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) participant user files for all elective colon cancer cases from 1/2016 through 12/2021 performed with minimally invasive surgical techniques (robotic and laparoscopic).
View Article and Find Full Text PDFInvestigating the Obesity Paradox in Colorectal Cancer: An Analysis of Prospectively Collected Data in a Diverse Cohort.
Cancers (Basel)
August 2024
Sylvester Comprehensive Cancer Center, Miller School of Medicine at the University of Miami, Miami, FL 33136, USA.
Article Synopsis
- A study examined the impact of pre-diagnosis body mass index (BMI) trajectories on mortality in patients with colorectal cancer, utilizing data from the Multiethnic Cohort over a period of 26 years.
- Out of 924 participants, results showed no significant link between BMI changes before cancer diagnosis and overall or cancer-specific mortality, although certain demographics like race and lifestyle factors had notable effects.
- The research concluded that pre-diagnosis BMI trajectories do not influence mortality after colorectal cancer diagnosis, highlighting that other factors such as ethnicity, smoking, and diabetes play a more significant role.
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