Background: multi-compartment medication devices (MMDs) are widely used, primarily by older people, to aid correct-medication taking. Several MMD types are available yet little is known about the ease with which patients with varying functional ability use these devices and whether some types are easier than others. Such knowledge would assist healthcare practitioners in advising patients on a suitable choice of device.
Objective: this study investigates the ease with which patients with differing functional ability use three types of MMD.
Method: participants were recruited from an older person's medical ward. Demographic and medication information, cognitive function, visual acuity and manual dexterity were recorded. The Venalink®, Nomad Clear® and Dosett® MMDs were tested. Participants rated each MMD according to text readability, ease of opening, ease of medication removal, transportability and overall rating. These ratings were compared between MMDs for all patients and for subgroups with differing functional abilities.
Results: the MMDs were trialled by 50 patients; the majority rated text readability well but rated MMDs poorly according to the other criteria. Cognitively impaired participants may encounter difficulties in opening and removing medication from Venalink® and Nomad®. The Dosett® consistently rated better across all criteria. Transportability was the most influential criterion for overall MMD usability.
Conclusion: the poor patient rating of MMDs which are widely used in practice is of concern. Some MMDs may be difficult to open and access, especially for patients with cognitive impairment. This offers some guidance to health professionals in advising patients on MMD choice however, overall MMD rating appears dominated by transportability.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1093/ageing/aft113 | DOI Listing |
Magn Reson Med
January 2025
School of Medicine and Health, Institute for Diagnostic and Interventional Neuroradiology, Technical University of Munich, Munich, Germany.
Purpose: In brain tumors, disruption of the blood-brain barrier (BBB) indicates malignancy. Clinical assessment is qualitative; quantitative evaluation is feasible using the K leakage parameter from dynamic susceptibility contrast MRI. However, contrast agent-based techniques are limited in patients with renal dysfunction and insensitive to subtle impairments.
View Article and Find Full Text PDFOpen Res Eur
November 2024
Department for Neuro- and Sensory Physiology, University Medical Center Göttingen, Göttingen, 37077, Germany.
Background: Finding appropriate model parameters for multi-compartmental neuron models can be challenging. Parameters such as the leak and axial conductance are not always directly derivable from neuron observations but are crucial for replicating desired observations. The objective of this study is to replicate the attenuation behavior of an excitatory postsynaptic potential (EPSP) traveling along a linear chain of compartments on the analog BrainScaleS-2 neuromorphic hardware platform.
View Article and Find Full Text PDFiScience
December 2024
Institute of AI for Health, Helmholtz Munich - German Research Centre for Environmental Health, Neuherberg, Germany.
The Bruton tyrosine kinase inhibitor ibrutinib is an effective treatment for patients with chronic lymphocytic leukemia (CLL). While it rapidly reduces lymph node and spleen size, it initially increases the number of lymphocytes in the blood due to cell redistribution. A previously published mathematical model described and quantified those cell kinetics.
View Article and Find Full Text PDFActa Neurochir (Wien)
October 2024
Department of Neurosurgery, University of Colorado Anschutz Medical Campus School of Medicine, Aurora, CO, USA.
Brain Commun
September 2024
Neuorimaging Unit, Neuroimmunology Division, Department of Neurology, Vanderbilt University Medical Center (VUMC), Nashville, TN 37232, USA.
Histopathologic studies report higher concentrations of multiple sclerosis white matter lesions in watershed areas of the brain, suggesting that areas with relatively lower oxygen levels may be more vulnerable to disease. However, it is unknown at what point in the disease course lesion predilection for watershed territories begins. Accordingly, we studied a cohort of people with newly diagnosed disease and asked whether (1) white matter lesions disproportionally localize to watershed-regions and (2) the degree of microstructural injury in watershed-lesions is more severe.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!