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Identification of Fungus-Derived Natural Products as New Antigiardial Scaffolds.
Microbiol Spectr
June 2023
Department of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington, Seattle, Washington, USA.
Article Synopsis
- There's a significant need for effective treatments for giardiasis, a disease caused by the parasite Giardia lamblia, especially since many current drugs are becoming ineffective due to resistance.
- This study screened natural products and fungal extracts, discovering new classes of compounds that inhibit G. lamblia growth, suggesting potential alternative therapies.
- The findings advocate for developing inexpensive, nature-derived drugs to address giardiasis, particularly in impoverished communities where it causes severe health issues in children.
Characterization of Metronidazole-Resistant Lines by Comparative Transcriptomics and Proteomics.
Front Microbiol
February 2022
Department of Cell and Molecular Biology, Biomedical Center (BMC), Uppsala University, Uppsala, Sweden.
Metronidazole (MTZ) is a clinically important antimicrobial agent that is active against both bacterial and protozoan organisms. MTZ has been used extensively for more than 60 years and until now resistance has been rare. However, a recent and dramatic increase in the number of MTZ resistant bacteria and protozoa is of great concern since there are few alternative drugs with a similarly broad activity spectrum.
View Article and Find Full Text PDFParadigms of Protist/Bacteria Symbioses Affecting Human Health: and .
Front Microbiol
January 2021
Dipartimento di Scienze Biomediche, Università degli Studi di Sassari, Sassari, Italy.
Ever since the publication of the seminal paper by Lynn Margulis in 1967 proposing the theory of the endosymbiotic origin of organelles, the study of the symbiotic relationships between unicellular eukaryotes and prokaryotes has received ever-growing attention by microbiologists and evolutionists alike. While the evolutionary significance of the endosymbiotic associations within protists has emerged and is intensively studied, the impact of these relationships on human health has been seldom taken into account. Microbial endosymbioses involving human eukaryotic pathogens are not common, and the sexually transmitted obligate parasite and the free-living opportunistic pathogen represent two unique cases in this regard, to date.
View Article and Find Full Text PDFpH-Dependent Molecular Gate Mesoporous Microparticles for Biological Control of .
Pharmaceutics
January 2021
Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico, Universitat Politècnica de València and Universitat de València, Camino de Vera s/n, 46022 Valencia, Spain.
Giardiasis is a parasitism produced by the protozoa that lives as trophozoite in the small intestine (mainly in the duodenum) attached to the intestinal villus by means of billed discs. The first line treatment is metronidazole, a drug with high bioavailability, which is why to obtain therapeutic concentrations in duodenum, it is necessary to administer high doses of drug to patients with the consequent occurrence of side effects. It is necessary to developed new therapeutical approaches to achieve a local delivery of the drug.
View Article and Find Full Text PDFNatural Infection with Is Associated with Altered Community Structure of the Human and Canine Gut Microbiome.
mSphere
August 2020
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Enteric parasitic infections are among the most prevalent infections in lower- and middle-income countries (LMICs) and have a profound impact on global public health. While the microbiome is increasingly recognized as a key determinant of gut health and human development, the impact of naturally acquired parasite infections on microbial community structure in the gut, and the extent to which parasite-induced changes in the microbiome may contribute to gastrointestinal symptoms, is poorly understood. Enteric parasites are routinely identified in companion animals in the United States, presenting a unique opportunity to leverage this animal model to investigate the impact of naturally acquired parasite infections on the microbiome.
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