The formal syntheses of -methylwelwitindolinone C isothiocyanate () and several other welwitindolinones - were achieved by the independent synthesis of . The synthesis featured a Lewis acid-mediated coupling between a heteroaryl carbinol and bis-TMS enol ether, an intramolecular enolate arylation, and an unprecedented intramolecular allylic alkylation of a γ-acyloxyenone.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748834 | PMC |
http://dx.doi.org/10.1016/j.tet.2013.03.010 | DOI Listing |
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