AI Article Synopsis
Article Abstract
The epigenetic status of cancer cells is a consequence of the neoplastic transformation of their normal counterpart. Epigenetic changes directly influence gene expression and chromatin organization, which consequently leads to escape from the tumor-suppression mechanisms. Global mapping for specific epigenetic modifications (e.g., DNA methylation) of the entire genome is required to reveal epigenetic hotspots associated with a cancer type/stage. DNA tiling arrays may be applied for genome-wide analysis of different epigenetic marks. Tiling arrays are high-density DNA microarrays that can be custom-made to survey regions of interest (e.g., gene promoters) or permit whole-genome analysis. To identify the genomic alterations associated with testicular cancers we used tiling arrays to profile their methylome. We successfully identified numerous epigenetically modified loci that arose as a consequence of tumor progression.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/978-1-62703-607-8_6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Rapid, inexpensive multiplex pathogen detection using resequencing microarrays.
J Virol Methods
January 2025
Centrillion Technologies, Palo Alto, CA 94303, United States.
Humanity faces an ongoing battle at the microscopic level to identify, contain, and treat outbreaks of numerous pathogens each year. Global genomic surveillance is the first step in monitoring outbreaks, but high-throughput methods are expensive and time-consuming. To solve this problem, we designed and manufactured a resequencing microarray capable of identifying 35 viral pathogens, 21 pathogenic bacteria, 16 antibiotic resistance genes, and 6 controls.
View Article and Find Full Text PDFConstruction of Double-layered DNA Tiles and Arrays from Double Crossover Motifs.
Chembiochem
January 2025
State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, 163 Xianlin Avenue, Nanjing, 210023, P. R. China E-amil.
DNA double crossover (DX) motifs including DAE (double crossover, antiparallel, even spacing) and DAO (double crossover, antiparallel, odd spacing) are well-known monolayered DNA building blocks for construction of 2D DNA arrays and tubes in nanoscale and microscale. Compared to the 3D architectures of DNA origami and single-stranded DNA bricks to build nanoscale 3D bundles, tessellations, gears, castles, etc., designs of double- and multi-layers of DX motifs for 3D architectures are still limited.
View Article and Find Full Text PDFSeries-Fed Microstrip Patch Antenna Array with Additive-Manufactured Foldable Honeycomb-Shaped Substrate.
Micromachines (Basel)
November 2024
Metamagnetics Inc., Marlborough, MA 01581, USA.
This paper presents a novel foldable S-band microstrip patch antenna array operating in the 2.4-2.45 GHz band.
View Article and Find Full Text PDFPeriodic ER-plasma membrane junctions support long-range Ca signal integration in dendrites.
Cell
January 2025
HHMI Janelia Research Campus, Ashburn, VA 20147, USA. Electronic address:
Neuronal dendrites must relay synaptic inputs over long distances, but the mechanisms by which activity-evoked intracellular signals propagate over macroscopic distances remain unclear. Here, we discovered a system of periodically arranged endoplasmic reticulum-plasma membrane (ER-PM) junctions tiling the plasma membrane of dendrites at ∼1 μm intervals, interlinked by a meshwork of ER tubules patterned in a ladder-like array. Populated with Junctophilin-linked plasma membrane voltage-gated Ca channels and ER Ca-release channels (ryanodine receptors), ER-PM junctions are hubs for ER-PM crosstalk, fine-tuning of Ca homeostasis, and local activation of the Ca/calmodulin-dependent protein kinase II.
View Article and Find Full Text PDFA Self-Assembled Periodic Nanoporous Framework in Aqueous Solutions of the DNA Tetramer GCCG.
ACS Nano
December 2024
Department of Physics and Soft Materials Research Center, University of Colorado, Boulder, Colorado 80309-0390, United States.
Article Synopsis
- Researchers have found that high concentrations of the DNA 4-base oligomer GCCG can lead to the spontaneous formation of three-dimensional (3D) structures in aqueous solutions, expanding the field of DNA nanoscience.
- The GCCG oligomer forms double helices that create ordered arrangements resembling liquid crystal phases, allowing for complex structural organization even at high concentrations.
- At concentrations over 400 mg/mL, a new 3D body-centered cubic lattice framework develops, which could have practical applications in nanoscale templating and selection due to its unique properties and stability.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!