Purpose: To describe a technique to completely replace the donor corneal carrier of an existing type 1 Boston keratoprosthesis (KPro) that preserves the hardware intact.
Methods: Two eyes with sterile corneal melts around the KPro stem underwent a complete exchange of the donor corneal carrier. Donor corneas were prepared in the usual fashion for KPro and were then left uncovered to dehydrate. Meanwhile, the melted corneas were excised in a manner similar to that for failed penetrating grafts and uncollared from the KPro. The new donors were then sufficiently thinned to slide between the back and front plates; however, to clear the 5.0-mm KPro front plate flange, the central 3.0-mm opening in the replacement donor corneas was first enlarged by means of 2 paired sub-1.0-mm radial relaxing incisions placed 180 degrees apart. Once positioned, the new donor carriers were rehydrated to seal the space between the back and front plates.
Results: The full-thickness corneal carrier was successfully replaced in both cases. In 1 case, scarring of the back plate holes caused the plate to behave like an intact Descemet membrane during deep anterior lamellar keratoplasty.
Conclusions: When an otherwise functional KPro is jeopardized because of disorders of the donor corneal carrier, it can be advantageous to selectively replace the carrier and thus salvage the original KPro. We describe such a rescue technique, which permits the exchange of the corneal carrier without disassembling the KPro.
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http://dx.doi.org/10.1097/ICO.0b013e31829e1fc0 | DOI Listing |
Cornea
January 2025
Chongqing Eye and Vision Care Hospital Aier Eye Hospital Group, Yu Zhong, Chongqing, China.
Purpose: A detailed study of the physicochemical properties of SMILE-derived lenticules and evaluation of their drug delivery after loading with silver nanoparticles (AgNPs).
Methods: The lenticules were decellularized and modified with crosslinking concentrations of 0.01 (0.
Biomater Sci
January 2025
Department of Chemical Engineering, University of Waterloo, 200 University Avenue West, Waterloo, ON N2L 3G1, Canada.
The treatment of corneal blindness due to corneal diseases and injuries often requires the transplantation of healthy cadaveric corneal endothelial graft tissue to restore corneal clarity and visual function. However, the limited availability of donor corneas poses a significant challenge in meeting the demand for corneal transplantation. As a result, there is a growing interest in developing strategies alleviate this unmet need, and one of the postulated approaches is to isolate and expand primary human corneal endothelial cells (HCECs) for use in cell therapy.
View Article and Find Full Text PDFJ Med Cases
January 2025
Department of Dermatology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama City 700-8558, Japan.
Conjunctival malignant melanoma is extremely rare, with no standard of care established at moment. Here we report a 65-year-old woman, as a hepatitis B virus (HBV) carrier, who presented concurrently a liver mass and lower bulbar conjunctival pigmented lesions in the right eye. Needle liver biopsy and excisional conjunctival biopsy showed hepatocellular carcinoma and conjunctival malignant melanoma , respectively.
View Article and Find Full Text PDFInt J Pharm
December 2024
Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028, Barcelona, Spain; Institute of Nanoscience and Nanotechnology (IN(2)UB), University of Barcelona, 08028 Barcelona, Spain. Electronic address:
Ocular inflammation is a complex pathology with limited treatment options. While traditional therapies have side effects, novel approaches, such as natural compounds like Apigenin (APG) and Melatonin (MEL) offer promising solutions. APG and MEL, in combination with nanostructured lipid carriers (NLC), may provide a synergistic effect in treating ocular inflammation, potentially improving patient outcomes and reducing adverse effects.
View Article and Find Full Text PDFChem Asian J
December 2024
Department of Biomedical Engineering, Indian Institute of Technology Ropar, Rupnagar, 140001, Punjab, India.
Ocular drug-delivery is one of the most challenging areas owing to nature of ocular tissues. Various nanoformulations have been designed and investigated for drug-delivery to achieve high drug bioavailability. The major focus of these preparations available in market is to utilize nanomaterial as drug-carrier only, with less focus on developing functional-nanomaterials, which is a key knowledge gap in the field.
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