AI Article Synopsis
- The study involved creating a complex using 6-methylenandrosta-4-ene-3,17-dione and Hydroxypropyl-β-cyclodextrin (HP-β-CD) to facilitate the production of the antitumor drug exemestane by the bacteria Arthrobacter simplex ATCC6946.
- The complex was evaluated with techniques like UV, DSC, and TG, while the final products were analyzed using HPLC, NMR, and MS, confirming the successful development of the drug.
- The findings indicated that β-cyclodextrin improved the water-solubility and biocompatibility of the precursor, suggesting potential applications for other poorly soluble compounds in biotransformation processes.
Article Abstract
In this study, 6-methylenandrosta-4-ene-3,17-dione and Hydroxypropyl-β-cyclodextrin (HP-β-CD) were used to form a complex, which could be then biotransformed by Arthrobacter simplex ATCC6946 to obtain the antitumor drug exemestane. The complex was analyzed by UV, DSC and TG techniques, while the products were analyzed by HPLC, NMR and MS. These results confirmed that the β-cyclodextrin not only improved the water-solubility of 6-methylenandrosta-4-ene-3,17-dione, but also greatly enhanced the biocompatibility during the biotransformation process. This result may be applied to other precursors which have poor aqueous solubility in the biotransformation processes.
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| http://dx.doi.org/10.1016/j.steroids.2013.07.009 | DOI Listing |
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