Background: There is no proven pharmacological strategy for the treatment of the failing systemic right ventricle (SRV) but myocardial fibrosis may play a role in its pathophysiology.
Methods: We designed a double-blind, placebo-controlled clinical trial to assess the effects of eplerenone 50mg during 12 months on cardiac magnetic resonance parameters (SRV mass and ejection fraction) and neurohormonal and collagen turnover biomarker (CTB) levels.
Results: Twenty six patients with atrial switch repair for transposition of the great arteries were randomized to eplerenone (n=14) or placebo (n=12) and 14 healthy volunteers served as controls for comparison of baseline neurohormones and CTB levels. The study population showed a good baseline profile in terms of SRV mass (57.4 ± 17 g/m(2)) and ejection fraction (54.9 ± 7.5%). However, levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), C terminal propeptide of type I procollagen (CICP) and C-terminal Telopeptide of type I Collagen (ICTP) were significantly elevated when compared to healthy controls. After one year of treatment, a trend toward reduction of CICP, N-terminal pro-Matrix Metalloproteinase 1 (NT-proMMP1), Tissue Inhibitor of Metalloproteinases 1 (TIMP1) and galectin 3 levels and a lower increase in ICTP in patients under eplerenone was observed. The reduction of SRV mass and the improvement of SRV function with eplerenone were not conclusive.
Conclusions: Patients with SRV treated with eplerenone showed an improvement of an altered baseline CTB profile suggesting that reduction of myocardial fibrosis might be a therapeutic target in these patients.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijcard.2013.07.163 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Digital replica to unveil the impact of growing conditions on orange postharvest quality.
Sci Rep
June 2024
Laboratory for Biomimetic Membranes and Textiles, Empa, Swiss Federal Laboratories for Materials Science and Technology, Lerchenfeldstrasse 5, CH-9014, St. Gallen, Switzerland.
The postharvest end-quality of citrus is significantly impacted by pre-harvest factors such as weather, which varies among growing regions. Despite the importance of these factors, the influence of regional weather variations, such as variations in temperature, humidity, wind, vapor pressure deficit (VPD), and solar radiation on postharvest citrus quality, is largely unknown. This study aims to quantify this impact through a physics-driven digital replica of the entire value chain of Valencia oranges, from orchards in South Africa to retail in Europe.
View Article and Find Full Text PDFChristchurch Heterozygosity and Autosomal Dominant Alzheimer's Disease.
N Engl J Med
June 2024
From Massachusetts General Hospital (Y.T.Q., J.S.S., S.L., C.V.-C., L.R.G., E.K., K.J., R.A.S.), the Departments of Neurology (Y.T.Q., J.S.S., L.R.G., K.J., R.A.S.), Psychiatry (Y.T.Q., S.L., C.V.-C., E.K.), and Ophthalmology (P.P.-C., J.F.A.-V.), Harvard Medical School, Brigham and Women's Hospital (K.J., R.A.S.), and Schepens Eye Research Institute, Mass Eye and Ear (P.P.-C., J.F.A.-V.) - all in Boston; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia (Y.T.Q., D.A., D.C.A-A., D.V., Y.Z., A.Y.B., L.M., L.H., R.P.-D., G.G., S.R.V., J.A.O., P.V.-C., F.L.); the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.L.L., N.D.V.-M., S.K., M.G., D.S-F.); the Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara (K.S.K.); and the Banner Alzheimer's Institute, Phoenix, the University of Arizona, Tucson, and Arizona State University, Tempe - all in Arizona (E.M.R.).
Background: Variants in and (encoding apolipoprotein E and presenilin 1, respectively) alter the risk of Alzheimer's disease. We previously reported a delay of cognitive impairment in a person with autosomal dominant Alzheimer's disease caused by the variant who also had two copies of the apolipoprotein E3 Christchurch variant ( ). Heterozygosity for the variant may influence the age at which the onset of cognitive impairment occurs.
View Article and Find Full Text PDFOptimizing in-situ CO mineralisation: geomechanics and scalability in dunite and serpentinite rocks - Examples from Australia and New Zealand.
Sci Total Environ
June 2024
School of Civil Engineering, The University of Queensland, St. Lucia, 4072, QLD, Australia.
The collective drive towards achieving net-zero greenhouse gas emissions by 2050 has spurred interest in engineering solutions for carbon capture and storage worldwide. One such approach involves the permanent storage of CO in earth-abundant Ca-, Fe-, and Mg-bearing silicate rocks and minerals as carbonates via the process of CO mineralisation. This necessitates a thorough understanding of carbonate conversion under geologically relevant conditions.
View Article and Find Full Text PDFNext-generation tourniquet: Recommendations for future capabilities and design requirements.
J Trauma Acute Care Surg
June 2024
From the U.S. Army Institute of Surgical Research, U.S. Army Medical Research and Development Command (S.R.V., J.F.M., D.R.H., K.L.R., J.S., J.F.K.), San Antonio, Texas; and Oregon State University College of Engineering (D.R.H.), Corvallis, Oregon.
Article Synopsis
- Advances in tourniquet technology aim to address the needs of military and civilian scenarios, focusing on creating smart tourniquets with enhanced features.
- A modified Delphi technique was used to gather input from 34 experts through surveys and discussions to identify important design characteristics for these tourniquets.
- Key features identified include prolonged usage, ease of application by anyone, data display capabilities, semi-automated functions, and automated monitoring systems that offer notifications and recommended actions.
Background: The SARS-CoV-2 omicron (B.1.1.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!