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Dynamic susceptibility contrast-enhanced MRI with USPIO in evaluating angiogenesis of the peri-infarction zones in subacute ischemic stroke in a permanent middle cerebral artery occlusion rat model.
Acta Radiol
December 2024
Department of Radiology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China.
Article Synopsis
- The study explores the use of dynamic susceptibility contrast-enhanced magnetic resonance imaging (DSC-MRI) with ultrasmall superparamagnetic particles of iron oxides (USPIO) to assess angiogenesis in ischemic stroke in rats.
- It involved 21 rats divided into groups and measured various imaging parameters over different days after inducing a permanent middle cerebral artery occlusion (pMCAO).
- Results showed significant increases in relative cerebral blood volume (rCBV) and relative cerebral blood flow (rCBF) in the peri-infarction areas over time, indicating their potential in evaluating blood vessel growth during the stroke recovery phase.
Delayed Ferumoxtran-10-Enhanced Magnetic Resonance Neurography of the Lumbosacral Plexus: Impact on Vascular Suppression and Image Quality.
J Magn Reson Imaging
September 2024
Institute of Diagnostic and Interventional Radiology, University Hospital Zurich (USZ), Zurich, Switzerland.
Background: Intravenous Ferumoxtran-10 belongs to ultra-small superparamagnetic iron oxide particles and can be used for magnetic resonance neurography (MRN) as an alternative to other imaging methods which use contrast agents.
Purpose: To examine the impact of intravenous Ferumoxtran-10 on vascular suppression and compare image quality to gadolinium (Gd)-enhanced image acquisition in MRN of lumbosacral plexus (LS).
Study Type: Prospective.
Ferumoxtran-10-enhanced MRI for pre-operative metastatic lymph node detection in pancreatic, duodenal, or periampullary adenocarcinoma.
Eur Radiol
December 2024
Department of Medical Imaging, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Objectives: To assess 3-Tesla (3-T) ultra-small superparamagnetic iron oxide (USPIO)-enhanced MRI in detecting lymph node (LN) metastases for resectable adenocarcinomas of the pancreas, duodenum, or periampullary region in a node-to-node validation against histopathology.
Methods: Twenty-seven consecutive patients with a resectable pancreatic, duodenal, or periampullary adenocarcinoma were enrolled in this prospective single expert centre study. Ferumoxtran-10-enhanced 3-T MRI was performed pre-surgery.
Precision USPIO-PEG-SLe Nanotheranostic Agent Targeted Photothermal Therapy for Enhanced Anti-PD-L1 Immunotherapy to Treat Immunotherapy Resistance.
Int J Nanomedicine
February 2024
Department of Radiology, Guangxi Medical University Cancer Hospital, Nanning, 530021, People's Republic of China.
Background: The anti-Programmed Death-Ligand 1 (termed aPD-L1) immune checkpoint blockade therapy has emerged as a promising treatment approach for various advanced solid tumors. However, the effect of aPD-L1 inhibitors limited by the tumor microenvironment makes most patients exhibit immunotherapy resistance.
Methods: We conjugated the Sialyl Lewis X with a polyethylene glycol-coated ultrasmall superparamagnetic iron oxide (USPIO-PEG) to form UPS nanoparticles (USPIO-PEG-SLe, termed UPS).
A novel magnetic resonance tuning-magnetic relaxation switching sensor based on Gd-MOF/USPIO assembly for sensitive and convenient aflatoxin B1 detection.
Food Chem
June 2024
Hunan Provincial Key Laboratory of Cytochemistry, School of Food Science and Bioengineering, Changsha University of Science & Technology, Changsha 410114, Hunan, China; State Key Laboratory of Utilization of Woody Oil Resource, Hunan Academy of Forestry, Changsha 410004, Hunan, China. Electronic address:
Aflatoxin B1 (AFB1) can accumulate in different organs or tissues and seriously harm humans. Traditional magnetic relaxation switching (MRS) sensors have relatively low sensitivity, but are complex to use. Rapid small-trace molecule analysis in complex samples is challenging.
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