AI Article Synopsis
- Three new neolignans, 9-methoxyobovatol, magnobovatol, and 2-hydroxyobovaaldehyde, were isolated from Magnolia obovata along with six known compounds using chromatography.
- Spectroscopic techniques like EIMS, IR, and various NMR methods were employed to establish the chemical structures of these compounds.
- The isolated compounds exhibited significant inhibition of nitric oxide production in RAW 264.7 cells, with specific IC50 values indicating effectiveness without notable toxicity.
Article Abstract
Three new neolignans, named 9-methoxyobovatol (6), magnobovatol (7), and 2-hydroxyobovaaldehyde (9), along with six known ones, magnolol (1), honokiol (2), isomagnolol (3), obovatol (4), obovatal (5), and obovaaldehyde (8), were isolated from the fruits of Magnolia obovata using silica gel and ODS column chromatography. From the results of spectroscopic data including EIMS, IR, 1H- and 13C-NMR, DEPT, and 2D-NMR (gCOSY, gHSQC, gHMBC), the chemical structures were determined. All isolated compounds were evaluated for inhibition activity on nitric oxide production in LPS-induced RAW 264.7 cells, and compounds 1-4, 6, 7, and 9 showed significant activity with IC50 values of 15.8 ± 0.3, 3.3 ± 1.2, 14.1 ± 0.9, 6.2 ± 1.2, 14.8 ± 2.3, 14.2 ± 1.2, and 14.8 ± 3.2 µM, respectively, without any visible toxic effect.
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| http://dx.doi.org/10.1055/s-0033-1350673 | DOI Listing |
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