This paper describes the development of a referenced Electrochemical Paper-based Analytical Device (rEPAD) comprising a sample zone, a reference zone, and a connecting microfluidic channel that includes a central contact zone. We demonstrated that the rEPADs provide a simple system for direct and accurate voltammetric measurements that are referenced by an electrode with a constant, well-defined potential. The performance of the rEPADs is comparable to commercial electrochemical cells, and the layout can be easily integrated into systems that permit multiplexed analysis and pipette-free sampling. The cost of this portable device is sufficiently low that it could be for single-use, disposable applications, and its method of fabrication is compatible with that used for other paper-based systems.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/c3lc50771h | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Sensitive non-enzymatic sensing of creatinine in urine using a novel paper-based electroanalytical device.
Talanta
December 2024
Key Laboratory of Consumer Product Quality Safety Inspection and Risk Assessment for State Market Regulation, Chinese Academy of Inspection and Quarantine, Beijing, China. Electronic address:
Accurate analysis of urinary creatinine levels is of great clinical significance. Non-enzymatic creatinine sensing systems (NECSs) have gained growing development because of higher stability and lower cost compared to enzymatic sensing systems. At present, there is a demand for simple approaches to develop NECSs with high sensitivity.
View Article and Find Full Text PDFAtomically Fe(Ⅲ) anchored metal-organic frameworks-based fluorescent nanozyme for smartphone-adopted chemiluminescence-fluorescence dual-mode analysis of Uric acid.
Anal Chim Acta
November 2024
Anhui Laboratory of Functional Coordinated Complexes for Materials Chemistry and Application, School of Chemical and Environmental Engineering, Anhui Polytechnic University, Wuhu, 241000, China; State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022, China. Electronic address:
Article Synopsis
- Chemiluminescence (CL) analysis has limitations in stability and reproducibility, which can lead to inaccurate results; a dual-mode detection system combining CL and fluorescence (FL) overcomes these issues by utilizing independent output signals.
- A novel chemiluminescence-fluorescence system was developed using an atomically Fe(Ⅲ) anchored nanozyme (PCN-224/Fe(Ⅲ)), enabling ultrasensitive detection of Uric Acid (UA) with detection limits as low as 2.45 × 10⁻⁷ M in CL and 1.99 × 10⁻⁶ M in FL.
- The study advances portable, efficient detection methods by integrating smartphone technology for visual
Screen printed 3D microfluidic paper-based and modifier-free electroanalytical device for clozapine sensing.
Analyst
November 2024
Friedrich-Alexander-Universität Erlangen-Nürnberg, Power-To-X Technologies, 90762 Fürth, Germany.
The increasing demand in healthcare for accessible and cost-effective analytical tools is driving the development of reliable platforms to the customization of therapy according to individual patient drug serum levels, of anti-psychotics in schizophrenia. A modifier-free microfluidic paper-based electroanalytical device (μPED) holds promise as a portable, sensitive, and affordable solution. While many studies focus on the working electrode catalysts, improvements by engineering aspects of the electrode arrangement are less reported.
View Article and Find Full Text PDFEnhancing sensitivity towards electrochemical miRNA detection using an affordable paper-based strategy.
Anal Bioanal Chem
August 2024
Department of Pharmacy, University of Naples "Federico II", Via Domenico Montesano 49, 80131, Naples, Italy.
In the era of liquid biopsy, microRNAs emerge as promising candidates for the early diagnosis and prognosis of cancer, offering valuable insights into the disease's development. Among all the existing analytical approaches, even if traditional approaches such as the nucleic acid amplification ones have the advantages to be highly sensitive, they cannot be used at the point-of-care, while sensors might be poorly sensitive despite their portability. In order to improve the analytical performance of existing electroanalytical systems, we demonstrate how a simple chromatographic paper-based disk might be useful to rationally improve the sensitivity, depending on the number of preconcentration cycles.
View Article and Find Full Text PDFElectrochemical Paper-Based Microfluidics: Harnessing Capillary Flow for Advanced Diagnostics.
Small
September 2024
Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zürich, Vladimir-Prelog-Weg 1, Zürich, 8093, Switzerland.
Electrochemical paper-based microfluidics has attracted much attention due to the promise of transforming point-of-care diagnostics by facilitating quantitative analysis with low-cost and portable analyzers. Such devices harness capillary flow to transport samples and reagents, enabling bioassays to be executed passively. Despite exciting demonstrations of capillary-driven electrochemical tests, conventional methods for fabricating electrodes on paper impede capillary flow, limit fluidic pathways, and constrain accessible device architectures.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!