Attenuated Salmonella enterica serovar Typhi strain Ty21a is an important vaccine for controlling typhoid fever and serves as an oral vector for delivering heterologous antigens. The key attenuating features of this randomly mutated strain remain in question. Genome sequencing has revealed 679 single nucleotide polymorphisms (SNPs), and will help define alterations contributing to Ty21a safety and immunogenicity.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751609 | PMC |
| http://dx.doi.org/10.1128/genomeA.00650-13 | DOI Listing |
Publication Analysis
Top Keywords
salmonella enterica
8
enterica serovar
8
serovar typhi
8
strain ty21a
8
genome sequence
4
sequence salmonella
4
typhi oral
4
oral vaccine
4
vaccine strain
4
ty21a attenuated
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!