Ultrastructural interrelations of myocytes with efferent axons have been studied in the wall of the frog urinary bladder. Structural peculiarities of axons making contacts and of those not making contacts with smooth myocytes have been revealed. Two forms of the myoaxonal contacts have been discovered: without axon plunging into cytoplasm of the myocyte and with plunging into it. Both forms are organized either by a fasciculus of axons, or by single axons, and they innervate either single myocytes, or their group. Not more than 10% of myocytes get efferent innervation, others are not innervated. In composition of the myoneural contact certain active zones are found, however, they do not possess any specific signs of the synapse. A morphological type of axons has been determined; they are supposed to be processes of local (vesical) neurons and innervate myocytes of a peculiar processive form.
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Purinergic Signal
November 2024
Department of Physiology and Cell Biology, School of Medicine, University of Nevada Reno, Reno, NV, 89557, USA.
The urinary bladder mucosa (urothelium and suburothelium/lamina propria) functions as a barrier between the content of the urine and the underlying bladder tissue. The bladder mucosa is also a mechanosensitive tissue that releases signaling molecules that affect functions of cells in the bladder wall interconnecting the mucosa with the detrusor muscle and the CNS. Adenosine 5'-triphosphate (ATP) is a primary mechanotransduction signal that is released from cells in the bladder mucosa in response to bladder wall distention and activates cell membrane-localized P2X and P2Y purine receptors on urothelial cells, sensory and efferent neurons, interstitial cells, and detrusor smooth muscle cells.
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July 2024
Laboratory for Drug Discovery and Development, Shionogi & Co., Ltd., 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.
Duplicate testes lined in series were observed in the right scrotum of a 6-week-old Sprague-Dawley rat in a single-dose toxicity study. Of the two right testicles, one was spherical and less than half the size of a normal testis. The other was oval-shaped, slightly smaller than a normal testis, and possessed clear, tortuous blood vessels similar to those of a normal testis.
View Article and Find Full Text PDFbioRxiv
March 2024
Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
The kidney functions as a finely tuned sensor to balance body fluid composition and filter out waste through complex coordinated mechanisms. This versatility requires tight neural control, with innervating efferent nerves playing a crucial role in regulating blood flow, glomerular filtration rate, water and sodium reabsorption, and renin release. In turn sensory afferents provide feedback to the central nervous system for the modulation of cardiovascular function.
View Article and Find Full Text PDFActa Histochem Cytochem
December 2023
Department of Anatomy, Tokyo Medical University, Tokyo, Japan.
Lymph nodes have contractile structures, but their distribution in a lymph node has been less considered in terms of facilitation of lymph flow. Axillary, inguinal, and mesenteric lymph nodes were collected from mice and human cadavers, and their sections were immunostained for alpha-smooth muscle actin (αSMA) and high molecular weight caldesmon (H-caldesmon). The αSMA-positive cells were localized in the capsule beneath the ceiling epithelium on the afferent side in both mice and humans.
View Article and Find Full Text PDFAdv Anat Embryol Cell Biol
November 2023
Department of Science, LIME, University Roma Tre, Rome, Italy.
The relationships between motor neurons and the skeletal muscle during development and in pathologic contexts are addressed in this Chapter.We discuss the developmental interplay of muscle and nervous tissue, through neurotrophins and the activation of differentiation and survival pathways. After a brief overview on muscular regulatory factors, we focus on the contribution of muscle to early and late neurodevelopment.
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