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Background: Esophageal and gastric cancer were among the top 10 most common cancers worldwide. In addition, sex-specific differences were observed in the incidence. Due to their anatomic proximity, the 2 cancers have both different but also shared risk factors and epidemiological features.
View Article and Find Full Text PDFEpidemiology and outcomes associated with MBL-producing Enterobacterales: A systematic literature review.
Int J Antimicrob Agents
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Pfizer Inc., Bucharest, Romania. Electronic address:
The increasing prevalence of infections due to metallo-β-lactamase (MBL)-producing Enterobacterales poses a serious concern given the limited treatment options available. This systematic literature review (SLR) describes the molecular epidemiology, geographical distribution, and clinical outcomes of such infections. Systematic searches of literature published between January 2013 and May 2023 were performed, and 39 studies with an MBL sample size of ≥25 isolates and ≥2 well-defined outcomes were eligible.
View Article and Find Full Text PDFImmune mechanisms in multiple sclerosis: CD3 levels on CD28+ CD4+ T cells link antibody responses to human herpesvirus 6.
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January 2025
Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China; Henan International Joint Laboratory of Intracerebral Hemorrhage and Brain Injury, Zhengzhou, Henan, China. Electronic address:
Compelling evidence suggests a significant association between antibody-mediated immune responses and multiple sclerosis (MS). However, the exact causal relationships between these immune responses and MS remain unclear. In this study, we conducted a comprehensive examination of the link between antibody-mediated immune responses and MS via Mendelian randomization (MR) analysis to identify specific infectious pathogens potentially involved in the onset and progression of MS.
View Article and Find Full Text PDFAn aptamer-based electrochemical sensor for the quantification of the malaria biomarker lactate dehydrogenase.
Biosens Bioelectron
January 2025
Barcelona Institute for Global Health (ISGlobal), Barcelona, 08036, Spain; INTERFIBIO Research Group, Departament d'Enginyeria Química, Universitat Rovira i Virgili, Tarragona, 43007, Spain. Electronic address:
Malaria is one of the most deadly infectious diseases, causing the death of hundreds of thousands of patients each year. Global efforts to combat malaria necessitate the implementation of novel rapid diagnostic tests deployable at the point of care. Here, we present the development of an electrochemical aptamer-based (EAB) sensor for the quantification of the malaria biomarker Plasmodium falciparum lactate dehydrogenase (PfLDH).
View Article and Find Full Text PDFTrends in psychological distress during and after the COVID-19 pandemic: Findings from a population-based Costa Rican cohort study.
Public Health
January 2025
Universidad de Costa Rica, San José, Costa Rica. Electronic address:
Objectives: The COVID-19 pandemic has resulted in an increase of psychological distress. We hypothesized that the mental health of individuals has improved since the end of the pandemic.
Study Design: 1459 population-based participants of the RESPIRA cohort study (Costa Rica) METHODS: Psychological distress was measured at 6-month intervals using the Mental Health Inventory 5 (MHI-5) during the 2-year follow-up.
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