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Safety of 1 mcg/mL as the starting dose in cluster protocol for hymenoptera immunotherapy.
Allergol Immunopathol (Madr)
January 2025
Department of Allergy and Clinical Immunology, Firooz Abadi Hospital, Iran University of Medical Sciences, Tehran, Iran;
Background: Hymenoptera venom allergy is a potentially severe allergic reaction in the general population. The only preventative approach in these cases is venom immunotherapy (VIT), which follows different protocols. The recommended initial dose is 0.
View Article and Find Full Text PDFStability-indicating spectrophotometric quantification of safinamide in the presence of its possible degradation product.
Sci Rep
January 2025
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Egyptian Russian University, Badr City, 11829, Cairo, Egypt.
In recent times, a truly exquisite pharmaceutical marvel has graced the world of medicine, known as Safinamide (SAF). This opulent creation has been specifically tailored to cater to the needs of individuals afflicted with Parkinson's disease (PD), an esteemed neurological condition renowned for its regal ability to impede motor skills, coordination, and equilibrium. It is highly improbable that degradation products of pharmaceutical components would significantly compromise efficiency and safety of a drug during its shelf life.
View Article and Find Full Text PDFWeather and Marine Aquaculture Workers' Safety in Atlantic Canada.
J Agromedicine
December 2024
Department of Geography, Memorial University of Newfoundland, St. John's, NL, Canada.
Objective: Marine aquaculture workers are at high risk of injury and fatalities. Understanding the role of weather in occupational safety and health (OSH) in marine aquaculture is important for work design, planning, and for safety management and hazard reduction, but there is limited research on this subject.
Methods: Using findings from a review of research and grey literature and from key informant interviews and roundtable discussions in Atlantic Canada, this paper explores the impact of weather-driven hazards on marine aquaculture in Northern and temperate regions, along with the strategies employed to mitigate these impacts.
Clinical Trial With a Depigmented, Polymerized Mite Mixture Extract at Maximum Concentrations.
Immun Inflamm Dis
December 2024
Medical Affairs and Clinical Department, LETI Pharma S.L.U., Madrid, Spain.
Background: Efficacy of allergen immunotherapy is dose-dependent; however, high doses of allergen may imply a greater risk of adverse reactions.
Objective: To assess the safety and tolerability of subcutaneous immunotherapy (SCIT) with mixtures of mite allergen extracts, Dermatophagoides pteronyssinus/Blomia tropicalis (Dpt/Bt) and Dermatophagoides pteronyssinus/Lepidoglyphus destructor (Dpt/Ld) at maximum concentrations, in adult patients with allergic rhinitis or rhinoconjunctivitis, and controlled allergic asthma due to a clinically relevant sensitisation to these mites.
Methods: An open-label, noncontrolled, nonrandomised, phase IIb clinical trial was carried out in three hospitals in Spain between September 2014 and May 2018.
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