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The meniscus effect in cell culture vessels limits the observable areas with phase contrast microscopy. For meniscus effect compensation in microtiter plates (MTPs), we present a method using an LCD to replace the fixed condenser annulus, which enables adaptive annulus shifting based on image analysis. This approach led to an increase in phase contrast area by a factor of 8.
View Article and Find Full Text PDFRamping Dynamics in the Frontal Cortex Unfold Over Multiple Timescales During Motor Planning.
J Neurophysiol
January 2025
Division, Department of Psychological and Brain Sciences, Boston University, Boston, MA.
Plans are formulated and refined throughout the period leading up to their execution, ensuring that the appropriate behaviors are enacted at the appropriate times. While existing evidence suggests that memory circuits convey the passage of time through diverse neuronal responses, it remains unclear whether the neural circuits involved in planning exhibit analogous temporal dynamics. Using publicly available data, we analyzed how activity in the mouse frontal motor cortex evolves during motor planning.
View Article and Find Full Text PDF[Molecular authentication of calcined oyster (Ostrea gigas) and its processed products].
Zhongguo Zhong Yao Za Zhi
December 2024
Experimental Research Center, China Academy of Chinese Medical Sciences Beijing 100700, China.
Calcined oyster is a commonly used shellfish traditional Chinese medicine in clinical practice in China. During the processing of oysters, their microscopic characteristics are destroyed, and open-fire calcination can damage the DNA of oysters, making it difficult to identify the primary source. The establishment of a specific polymerase chain reaction(PCR) method for the identification of calcined oysters can provide a guarantee for the safety and clinical efficacy of the medicine and its processed products.
View Article and Find Full Text PDFTesting and Validation of the Vehicle Front Camera Verification Method Using External Stimulation.
Sensors (Basel)
December 2024
CARISSMA Institute of Electric, Connected, and Secure Mobility (C-ECOS), Technische Hochschule Ingolstadt, Esplanade 10, 85049 Ingolstadt, Germany.
The perception of the vehicle's environment is crucial for automated vehicles. Therefore, environmental sensors' reliability and correct functioning are becoming increasingly important. Current vehicle inspections and self-diagnostics must be adapted to ensure the correct functioning of environmental sensors throughout the vehicle's lifetime.
View Article and Find Full Text PDFMIC: Breast Cancer Multi-label Diagnostic Framework Based on Multi-modal Fusion Interaction.
J Imaging Inform Med
January 2025
School of Information Engineering and Automation, Kunming University of Science and Technology, Kunming, Yunnan, China.
The automated diagnosis of low-resolution and difficult-to-recognize breast ultrasound images through multi-modal fusion holds significant clinical value. However, prevailing fusion methods predominantly rely on image modalities, neglecting the textual pathology information, and only benign and malignant diagnosis of breast tumors is not satisfying for clinical applications. Consequently, this paper proposes a novel multi-modal fusion interactive diagnostic framework, termed the MIC framework, to achieve the multi-label classification of breast cancer, namely benign-malignant classification and breast imaging reporting and data system (BI-RADS) 3, 4a, 4b, 4c, and 5 gradings.
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