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Altered LY6E and TRIM6 expression in PBMCs correlated with HBsAg clearance and response to Peg-IFN-α treatment in HBeAg-negative chronic hepatitis B patients.
Virol J
March 2025
Department of Infectious Diseases, Chongqing Key Laboratory of Infectious Diseases and Parasitic Diseases, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Background: Pegylated interferon alpha (Peg-IFN-α) has the potential to eradicate hepatitis B surface antigen (HBsAg). This study aimed to investigate whether the expression levels of lymphocyte antigen 6 family member E (LY6E) and tripartite motif-containing protein 6 (TRIM6) mRNAs in peripheral blood mononuclear cells (PBMCs) of hepatitis B e antigen (HBeAg)-negative chronic hepatitis B virus (HBV) patients is associated with the response to Peg-IFN-α treatment and HBsAg clearance.
Methods: In this prospective study, HBeAg-negative chronic HBV patients treated with Peg-IFN-α were followed for 48 weeks.
On the Specific Status of Rhinogobius zhoui (Gobiiformes, Gobiidae) with mtDNA Characterization.
Biochem Genet
March 2025
The Co-Innovation Center for Sustainable Forestry in Southern China, College of Life Sciences, Nanjing Forestry University, Nanjing, 210037, China.
Rhinogobius zhoui is found only in streams on Lianhua Mountain, Guangdong Province, China. Juveniles of Rhinogobius zhoui bred in an artificial environment do not undergo a planktonic period and have a landlocked life history. At present, there is not much published literature regarding this species.
View Article and Find Full Text PDFExperiences of stigma amongst healthcare professionals working in abortion care: a global survey.
BMJ Sex Reprod Health
March 2025
The Open University, Milton Keynes, UK
Introduction: Abortion-related stigma negatively affects healthcare professionals providing abortion care, threatening workforce well-being and service provision. This global study, part of the Royal College of Obstetricians and Gynaecologists' 'Making Abortion Safe' Project, explored healthcare providers' experiences of abortion stigma, its drivers and mitigating factors.
Methods: A global online survey was distributed to healthcare professionals trained to provide abortion and post-abortion care (PAC) through 16 partner organisations over a 6-week period in 2021.
State funding for cannabis research: an analysis of funding mechanisms and levels.
J Cannabis Res
March 2025
Cannabis Policy Lab, Sacramento, CA, USA.
Background: This paper examines cannabis research funding across U.S. states that have legalized cannabis for medical or adult (non-medical) use.
View Article and Find Full Text PDFHealthcare Professionals' Knowledge, Attitudes, and Practices Regarding Respiratory Syncytial Virus Disease and Vaccination in Adults Aged 60 Years and Older.
Infect Dis Ther
March 2025
GSK, Philadelphia, PA, USA.
Introduction: The burden of respiratory syncytial virus (RSV) disease is substantial among adults aged ≥ 60 years and adults with risk factors for severe RSV. This study assessed the knowledge, attitudes, and practices of healthcare professionals (HCPs) related to RSV disease and vaccination, with a focus on adults aged ≥ 60 years.
Methods: During November 14-30, 2023, a cross-sectional, web-based survey was administered to HCPs, targeting a total of 600 primary care physicians (PCPs), specialist physicians, nurse practitioners (NPs)/physician assistants (PAs), and pharmacists.
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