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Advances in RNA editing in hematopoiesis and associated malignancies.
Blood
January 2025
State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College; Center for Stem Cell Medicine,, Tianjin, China.
Adenosine-to-inosine (A-to-I) RNA editing is a prevalent RNA modification essential for cell survival. The process is catalyzed by the Adenosine Deaminase Acting on RNA (ADAR) enzyme family that converts adenosines in double-stranded RNAs (dsRNAs) into inosines, which are read as guanosines during translation. Deep sequencing has helped to reveal that A-to-I editing occurs across various types of RNAs to affect their functions.
View Article and Find Full Text PDFThe real rotational capacity of the human joints - the muscular and gravitational torques and the foot as a platform.
Acta Bioeng Biomech
September 2024
Jagiellonian University Medical College, Faculty of Medicine, Department of Bioinformatics and Telemedicine, Kraków, Poland.
The purpose was to answer what is the relationship between torques acting on the human body, how does the triceps calf muscle balance the weight of a tilted body and what is the foot's role in the titling body? Two research models were developed. Model 1 - the one-sided lever system consists of a flat bar with, an axis of rotation, used to determine the weight and torque at a given point on it. Model 2 - the two-sided lever system consists of a flat bar imitating a tilted body counteracted by the Achilles tendon, and a platform imitating a foot.
View Article and Find Full Text PDFNew and Emerging Biological Therapies for Myasthenia Gravis: A Focussed Review for Clinical Decision-Making.
BioDrugs
January 2025
Department of Neurology, Neuroscience Clinical Research Center (NCRC) and Integrated Myasthenia Gravis Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117, Charitéplatz 1, Germany.
Myasthenia gravis (MG) is a rare autoimmune disease characterised by exertion-induced muscle weakness that can lead to potentially life-threatening myasthenic crises. Detectable antibodies are directed against specific postsynaptic structures of the neuromuscular junction. MG is a chronic condition that can be improved through therapies, but to date, not cured.
View Article and Find Full Text PDFPhenomenology of Identity: Narrative Medicine Curricula in the Care of Eating Disorders.
J Med Humanit
January 2025
The University of North Carolina School of Medicine, 321 Columbia St, Chapel Hill, NC, 27514, USA.
A growing body of literature explores the intersection of eating disorders and identity formation-an entanglement that makes eating disorders particularly challenging to treat. Narrative medicine is a discipline of the health humanities that is interested in bearing witness to patients' stories with a closeness and rigor that enhances clinical care. The pedagogy of the field is the narrative medicine workshop, which mobilizes close-reading of works of art and reflective writing to improve our understanding of Self and Other.
View Article and Find Full Text PDFWhen Are Single Reader Evaluations Insufficient in Teledermoscopic Assessments? Analyses of a Retrospective Cohort Study.
Telemed J E Health
January 2025
Department of Clinical Sciences, Dermatology and Venereology, Lund Skin Cancer Research Group, Lund University, Lund, Sweden.
Teledermoscopy (TDS) emerges as an efficient tool for diagnosing skin lesions. In Sweden, double reading is the standard of care, but risk factors for misdiagnosis or mismanagement using single reader evaluations (SRE) are not well-studied. This study aimed to assess the accuracy of SRE compared with the gold standard in TDS.
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