Palladium(II)-catalyzed direct conversion of methyl arenes into aromatic nitriles.

Angew Chem Int Ed Engl

Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871 (China).

Published: September 2013

From methyl to nitrile: A mild ammoxidation method, which directly converts methyl arenes into aromatic nitriles, has been developed by using Pd(OAc)2 and N-hydroxyphthalimide (NHPI) as the catalysts, and tert-butyl nitrite as the nitrogen source and oxidant.

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http://dx.doi.org/10.1002/anie.201305731DOI Listing

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