[Spectrum of erythrocyte membrane lipids in various types of hypoglycemic therapy].

Changes in the lipid spectrum of red cell membrane (cholesterol, total and fractional phospholipids) were examined in 46 patients with newly detected non-insulin-dependent diabetes mellitus at the period of the disease diagnosis and over the course of therapy with various sugar-reducing drugs. Diabeton, a gliclazide series drug, has shown the most manifest compensatory effect on red cell membrane lipid shifts. Diets and biguanide therapy for 6-8 months failed to stably normalize the detected shifts; further correction appeared to be necessary in such cases.