Determination of diosmin in pharmaceutical formulations using Fourier transform infrared spectrophotometry.

Saudi Pharm J

Cromatec_plus srl, Analytical Research Department, 18 Sos. Cotroceni, Bucharest 6, 060114, Romania.

Published: October 2009

A Fourier transform infrared (FT-IR) spectrometric method was developed for the rapid, direct measurement of diosmin in different pharmaceutical drugs. Conventional KBr-spectra were compared for best determination of active substance in commercial preparations. The Beer-Lambert law and two chemometric approaches, partial least squares (PLS) and principal component regression (PCR+) methods, were tried in data processing.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730991PMC
http://dx.doi.org/10.1016/j.jsps.2009.10.008DOI Listing

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