Rodents contain in their genome more than 1000 functional odorant receptor genes, which are specifically expressed by the olfactory sensory neurons projecting from the olfactory epithelium to the olfactory bulb. Strong evidence for the presence and local translation of odorant receptor mRNAs in the axon of olfactory sensory neurons was obtained, but no function has been assigned to these axonal mRNAs yet. The aim of this review is to discuss the evidence for the presence and local translation of odorant receptor mRNAs in olfactory sensory axons, and to speculate on their possible function in the wiring of the mouse olfactory sensory projections.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879812 | PMC |
| http://dx.doi.org/10.1002/dneu.22122 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Single-Cell RNA-Sequencing of Zebrafish Olfactory Epithelium Identifies Odor-Responsive Candidate Olfactory Receptors.
Genes Cells
January 2025
Laboratory for Systems Molecular Ethology, RIKEN Center for Brain Science, Saitama, Japan.
Single-cell RNA-sequencing (scRNA-seq) is a powerful method to comprehensively overlook gene expression profiles of individual cells in various tissues, providing fundamental datasets for classification of cell types and further functional analyses. Here we adopted scRNA-seq analysis for the zebrafish olfactory sensory neurons which respond to water-borne odorants and pheromones to elicit various behaviors crucial for survival and species preservation. Firstly, a single-cell dissociation procedure of the zebrafish olfactory rosettes was optimized by using cold-active protease, minimizing artifactual neuronal activation.
View Article and Find Full Text PDFAuthor Correction: Conserved pattern-based classification of human odorant receptor multigene family.
Sci Rep
January 2025
Department of Brain Sciences, Graduate School, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, Republic of Korea.
Decoding Deception: The binding affinity of cuttlefish ink on shark smell receptors.
G3 (Bethesda)
January 2025
University College Dublin, School of Biology and Environmental Science, Belfield, Dublin 4, Ireland.
Chemical signaling can play a crucial role in predator-prey dynamics. Here, we present evidence that ink from the common cuttlefish (Sepia officinalis) targets olfactory receptor proteins in shark, potentially acting as a predator deterrence. We apply in silico 3D docking analysis to investigate the binding affinity of various odorant molecules to shark olfactory receptors of two shark species: cloudy catshark (Scyliorhinus torazame) and white shark (Carcharodon carcharias).
View Article and Find Full Text PDFExpression of V-ATPases in Olfactory Sensillum Support Cells.
Insects
December 2024
Department Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, 07745 Jena, Germany.
V-ATPases are ubiquitous and evolutionarily conserved rotatory proton pumps, which are crucial for maintaining various biological functions. Previous investigations have shown that a V-ATPase is present in the support cells of moth trichoid sensilla and influences their olfactory sensory neuron performance. Generally, V-ATPases are thought to regulate the pH value within the sensillum lymph, and aid K homeostasis within the sensillum.
View Article and Find Full Text PDFComprehensive Transcriptomic Analysis Reveals Cell-Type-Specific Roles of Human Odorant Receptors in Glioblastoma and the Tumor Microenvironment.
Int J Mol Sci
December 2024
Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Republic of Korea.
Odorant receptors (ORs), which constitute approximately 50% of all human G protein-coupled receptors, are increasingly recognized for their diverse roles beyond odor perception, including functions in various pathological conditions like brain diseases and cancers. However, the roles of ORs in glioblastoma (GBM), the most aggressive primary brain tumor with a median survival of only 15 months, remain largely unexplored. Here, we performed an integrated transcriptomic analysis combining The Cancer Genome Atlas RNA-seq and single-cell RNA sequencing data from GBM patients to uncover cell-type-specific roles of ORs within the tumor and its microenvironment.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!